| 摘要: |
| ［摘要］ 目的 观察吡格列酮与二甲双胍分别治疗2型糖尿病的临床效果。方法 将96例首次就诊诊断为2型糖尿病的患者半随机分为对照组和治疗组，各48例。对照组采用二甲双胍治疗，治疗组采用吡格列酮治疗。治疗1个月后，对两组的临床疗效、血糖水平改善情况及不良反应进行对比观察。结果 对照组总有效率为87.5%（42/48），治疗组总有效率为89.6%（43/48），两组治疗效果差异无统计学意义（P>0.05）；治疗组空腹血糖和餐后2 h血糖水平改善幅度略大于对照组(P>0.05)；对照组不良反应的发生率大于治疗组，差异有统计学意义（P<0.01）。结论 二甲双胍、吡格列酮均能有效控制2型糖尿病患者的血糖值。 |
| 关键词: 二甲双胍 吡格列酮 2型糖尿病 |
| DOI：10.3969/j.issn.1674-3806.2013.03.12 |
| 分类号:R 587.1 |
| 基金项目: |
|
| Comparison of the efficacy between pioglitazone and metformin in the treatment of patients with type 2 diabetes patients |
|
ZHANG De-cheng
|
|
Department of Internal Medicine,the First People’s Hospital of Zhangqiu,Shandong 250201,China
|
| Abstract: |
| ［Abstract］ Objective To compare the efficacy between pioglitazone and metformin in the treatment of patients with type 2 diabetes.Methods Ninety-six petients with type 2 diabetes were divided into a control group and a treatment group based on treatment order, each group had 48 patients. The control group were treated with metformin; the treatment group were treated with pioglitazone. One month after treatment, the control conditions of blood glucose were compared between two groups.Results After one month of the medication, the total effective rate of control group was 87.5%(42/48), that of the treatment group was 89.6%(43/48), there was no statistically significant difference between two groups(P>0.05). In treatment group, the fasting plasma glucose and 2 h postprandial blood sugar level improved slightly larger than the control group（P>0.05）; the incidence of adverse reactions of the control group was more than that of treatment group(P<0.01).Conclusion Metformin, pioglitazone can effectively control blood glucose of patients with type 2 diabetes. |
| Key words: Metformin Pioglitazone Type 2 diabetes |
