| 摘要: |
| ［摘要］ 目的 探讨酪氨酸激酶（SYK）在NK/T细胞淋巴瘤中的表达及意义。方法 应用免疫组织化学（SP）法检测SYK在外周NK/T细胞淋巴瘤组织标本中的表达情况，并分析其表达与年龄、性别、分期及细胞增殖指数等临床病理参数的关联性。结果 SYK在NK/T细胞淋巴瘤中高表达率为27.27%（15/55）；低表达率为72.73%（40/55），且与临床分期和细胞增殖指数有关。SYK高表达者具有较高的肿瘤分期和增殖指数。结论 NK/T细胞淋巴瘤中SYK表达上调与细胞增殖及临床分期有关，是其潜在的诊断和预后标记。 |
| 关键词: 外周T细胞淋巴瘤 SYK 免疫组织化学 |
| DOI：10.3969/j.issn.1674-3806.2013.05.01 |
| 分类号:R 551.2 |
| 基金项目:广西自然科学基金资助项目（编号：桂科自0899015） |
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| SYK expression in NK/T cell lymphoma and its significance |
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ZHANG Jie, XIAO Sheng-jun, SONG Tie-shan
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Department of Pathology,Guilin Medical University, Guangxi 541004, China
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| Abstract: |
| ［Abstract］ Objective To investigate the expression of SYK in NK/T cell lymphomas and its significance.Methods The expression of SYK in NK/T cell lymphoma was examined by immunohistochemisty assay to evaluate the relation between it`s expression and clinicopathological characters such as age, sex, stage and proliferation index.Results The percentage of NK/T-cell lymphoma with high expression of SYK was 27.27%(15/55).That with low expression of SYK was 72.73%(40/55).The expression of SYK was associated with tumour stage and cell proliferation index. NK/T lymphoma with high SYK expression had higher stage and proliferation index.Conclusion SYK overexpression is associated with tumour stage and cell proliferation in NK/T cell lymphomas, and is a potential diagnostic and prognostic factor. |
| Key words: Peripheral T-cell lymphomas SYK Immunohistochemisty |
