| 摘要: |
| ［摘要］ 目的 探讨血塞通联合雷公藤多苷治疗糖尿病肾病(DN)的疗效及安全性。方法 选择早期DN（Ⅲ期以前DN）患者80例，按确诊先后顺序分为治疗组和对照组各40例。对照组常规予积极调控血糖、血压、血脂、体重，同时口服雷公藤多苷治疗。治疗组在上述基础上加用血塞通注射剂治疗。观察两组患者治疗前后尿白蛋白排泄率(UAE)、血清胱抑素C（CysC）、肾小球滤过率（GFR）等变化。结果 两组治疗后组间比较，治疗组UAE低于对照组，差异有统计学意义(P<0.05)；治疗组CysC高于对照组，Cys-eGFR(Mac)低于对照组，但差异无统计学意义(P>0.05)；两组UAE及CysC均呈下降趋势，但治疗组下降幅度较对照组明显，差异有统计学意义(P<0.05)；两组Cys-eGFR(Mac)均升高，但增高幅度差异无统计学意义(P>0.05)。结论 在常规使用雷公藤多苷治疗的基础上，加用血塞通治疗早期DN疗效更佳。治疗中未见不良反应，安全性好，适合临床应用。 |
| 关键词: 糖尿病肾病 三七总皂苷 雷公藤多苷 |
| DOI：10.3969/j.issn.1674-3806.2013.05.21 |
| 分类号:R 587. 2 |
| 基金项目: |
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| Observation of curative effect on treating diabetic nephropathy by xuesaitong combined with tripterygium wilfordii polyglycoside |
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TANG Guo-chuan
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First Department of Internal Medicine，the People’s Hospital of Fangcheng District，Fangchenggang City,Guangxi 538021，China
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| Abstract: |
| ［Abstract］ Objective To investigate the curative effects and security of xuesaitong and tripterygium wilfordii polyglycoside in the treatment of diabetic nephropathy(DN).Methods Eighty patients with early DN(below stage Ⅲ of DN) were divided into the treatment group and control group with 40 patients in each group according to their diagnosing order，the control group was treated with routine including the positive regulation of blood glucose, blood pressure, blood lipid, body weight, while oral tripterygium wilfordii polyglycoside was administrated；the treatment group was treated with xuesaitong injection on the basis of above treatment. The two groups were observed before and after treatment of urinary albumin excretion rate(UAE), serum cystatin C(CysC), glomerular filtration rate(GFR) and other changes.Results In two groups after treatment, the UAE and CysC decreased, there was a statistically significant difference with each before treatment (P<0.05)；after treatment，the UAE and CysC in treatment group obviously decreased more than the control group, there was significant difference between two groups(P<0.05)；after treatment, Cys-eGFR(Mac) rose in the treatment group and was higher than that before treatment,there was a significant difference(P<0.05)；In the control group before and after treatment, there was no statistically significant difference in Cys-eGFR(Mac)(P>0.05).Conclusion On the basis of conventional and tripterygium wilfordii polyglycoside treatment, the curative effect is better in treatment of early DN with xuesaitong injection，and no adverse reactions is found, security is good, and it is suitable for clinical application. |
| Key words: Diabetic nephropathy(DN) Panaxnotoginseng saponins Tripterygium wilfordii polyglycoside |
