| 摘要: |
| ［摘要］ 目的 观察加味三黄汤冷冻液预防鼻咽癌颈部急性放射性皮肤损伤的临床疗效。方法 31例接受放射治疗的首诊鼻咽癌患者入组研究，颈部右侧涂抹加味三黄汤冷冻液为用药组，颈部左侧为空白对照组。结果 颈部右侧皮肤出现损伤的时间为(15.26±6.15)d，颈部左侧皮肤出现损伤时间为(11.14±5.28)d，差异有统计学意义（P<0.05）。用药组和对照组的皮肤反应发生率分别为74.19%(23/31)和87.10%(27/31)，差异无统计学意义（P>0.05）；两组皮肤损伤程度差异有统计学意义（P<0.05）。用药组和对照组重度疼痛发生率分别为35.48%和70.97%，差异有统计学意义（P<0.05）。皮肤反应用药组为13.04%(3/23)出现于照射20 Gy以前，对照组为59.26%(16/27)，差异有统计学意义（P<0.05）。结论 加味三黄汤冷冻液可预防鼻咽癌颈部放射性皮炎的发生，具有降低皮损程度的作用，值得进一步研究。 |
| 关键词: 辐射损伤 皮肤损伤 辐射防护剂 |
| DOI：10.3969/j.issn.1674-3806.2013.12.07 |
| 分类号:R 739.6 |
| 基金项目:广西卫生厅重点科研课题（编号：桂卫重200956） |
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| Clinical effect of frozen jiaweisanhuangtang in the prevention of radiation-induced neck skin damage in patients with nasopharyngeal carcinoma |
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ZHANG Zheng,WENG Jing-jin, YANG Jia-zhen, et al.
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Department of Otolaryngology Head and Neck Oncology，the People′s Hospital of Guangxi Zhuang Autonomous Region，Nanning 530021， China
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| Abstract: |
| ［Abstract］ Objective To observe the clinical effect of frozen jiaweisanhuangtang in the prevention of acute radiation-induced neck skin damage in patients with nasopharyngeal carcinoma.Methods Thirty-one patients with nasopharyngeal carcinoma undergoing radiotherapy were enrolled in the study, frozen jiaweisanhuangtang were applied to right-neck as treatment group, and left-neck were as a blank control group.Results The time of occurrence of skin injury at right-neck was (15.26±6.15)days, and the time at left-neck was (11.14±5.28)days, the difference was statistically significant(P<0.05). The incidence of skin damage in treatment group and control group were 74.19%(23/31) and 87.10%(27/31) respectively, the difference was not statistically significant(P>0.05); thus difference of degree of skin damage between two groups was statistically significant(P<0.05). The incidence of moderate to severe pain in treatment group and control group were 35.48% and 70.97% respectively, the difference was statistically significant(P<0.05). Thirteen point zero four percent of patients in treatment group showed skin damage before total 20 Gy of irradiation, and 59.26%(16/27) of patients showed in the control group, the difference was statistically significant(P<0.05).Conclusion The frozen jiaweisanhuangtang can effectively prevent the occurrence of acute radiation-induced neck skin damage, especially reduce the degree of skin damage, and it is worth further study. |
| Key words: Radiation injuries Skin damage Radiation protection agents |
