| 摘要: |
| ［摘要］ 目的 观察口服布洛芬治疗早产儿呼吸窘迫综合征（neonatal respriratory distress syndrome,NRDS）并动脉导管未闭（patent ductus arterious,PDA）的疗效和安全性。方法 选择呼吸窘迫综合征并动脉导管未闭早产儿38例，出生体重920～2 900 g，胎龄26.57～36.29周。口服布洛芬混悬滴剂10 mg·kg-1·次-1，连用3次。用药期间监测心率、血压、血氧饱和度、血糖、尿量、胆红素、电解质。用药前后检查血常规、肾功能、胆红素、超声心动图。结果 经治疗32例（84.21%）PDA关闭。治疗前后血常规、胆红素、尿量、血清肌酐水平均无明显改变。治疗前后血常规、胆红素、尿量、肾功能的变化与胎龄、出生体重、呼吸支持天数、呼吸支持方式、用药日龄与是否应用肺泡表面活性物质（pulmonary surfactant，PS）无关系。结论 口服布洛芬治疗早产儿NRDS并PDA安全有效。 |
| 关键词: 早产儿 新生儿呼吸窘迫综合征 动脉导管未闭 布洛芬 |
| DOI：10.3969/j.issn.1674-3806.2014.02.08 |
| 分类号:R 722 |
| 基金项目: |
|
| The observation on the efficiency and safety of oral ibuprofen in the treatment of premature infant with neonatal respiratory distress syndrome combined with patent ductus arterious |
|
YANG Han-hua, HUANG Yue-jun, WU Ruo-qi, et al.
|
|
Department of Neonatalogy, the 2nd Affiliated Hospital of Shantou University Medical College, Guangdong 515041, China
|
| Abstract: |
| ［Abstract］ Objective To investigate the efficiency and safety of oral ibuprofen in the treatment of premature infant with neonatal respiratory distress syndrome(NRDS) combined with patent ductus arterious(PDA).Methods Thirty-eight cases were included. The birth weight was between 920 g and 2 900 g, gestation age was between 26.57 weeks and 63.29 weeks. Ibuprofen suspension was given with dosage 10 mg/kg for 3 times. The heart rate, SaO2, blood pressure, blood glucose, urine output, bilirubin and electrolyte were monitored during the treatment. The renal function, CBC, bilirubin and echocardiogram were examined before and after the treatment.Results PDA was closed in 32 cases(84.21%). CBC, bilirubin, urine output, and serum creatinine did not show significant changes. The changes of CBC, bilirubin, urine output, renal function was not related with neither birth age, birth weight, days of breath support, method of breath support, day of drug given nor whether the application of pulmonary surfactant.Conclusion Oral ibuprofen is effective and safety in closing PDA in premature infant with NRDS. |
| Key words: Premature infant Neonatal respiratory distress syndrome Patent ductus arterious Ibuprofen |
