| 摘要: |
| ［摘要］ 目的 调查基层医院尿路感染病原菌的耐药现状,为临床治疗提供依据。方法 对2011-01～2011-12该院门诊、急诊和住院尿路感染患者尿液标本中分离出的316株病原菌进行鉴定和药敏试验。结果 尿路感染以革兰阴性杆菌为主，占73.7%，其中以大肠埃希菌占最大比例，为41.8%，其次是肺炎克雷伯菌、阴沟肠杆菌，分别为11.1%、5.1%；革兰阳性球菌占16.8%，其中以肠球菌和凝固酶阴性葡萄球菌多见，分别为10.1%、5.1%;真菌占9.5%，以假丝酵母菌为主。革兰阴性杆菌对碳青霉烯类、哌拉西林/他唑巴坦和阿米卡星有较高的敏感性;革兰氏阳性球菌对糖肽类抗菌药物呈100.0%敏感；假丝酵母菌对常用抗真菌药物敏感性较好。结论 尿路感染主要以肠杆菌科为主要致病菌，且具有较高的耐药性；经验用药前应积极进行病原学检查和药敏试验，以指导尿路感染的的合理用药，减少耐药菌的产生和传播。 |
| 关键词: 基层医院 尿路感染 病原菌 耐药性 |
| DOI：10.3969/j.issn.1674-3806.2014.02.21 |
| 分类号:R 969.3 |
| 基金项目: |
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| Investigation of drug resistance of pathogens causing urinary tract infection in grass-roots hospital |
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JIANG Xin，GAN Zheng-duan
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Department of Clinical Pharmacy,the People′s Hospital of Hengxian County,Guangxi 530300, China
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| Abstract: |
| ［Abstract］ Objective To investigate the drug resistance of pathogens causing urinary tract infection in grass-roots hospital，so as to provide evidence for clinical management.Methods From Jan. 2011 to Dec. 2011, a total of 316 strains of pathogens were isolated from urine specimens of inpatients and outpatients in the People′s Hospital of Hengxian,and drug sensitivity test was performed.Results The predominant pathogens of urinary tract infections were gram-negative bacteria, accounted for 73.7%, in which Escherichia coli ranked the first(41.8%), followed by Klebsiella pneumoniae(11.1%) and Enterobacter cloacae(5.1%). Gram-positive bacteria accounted for 16.8%, in which Enterococcus and coagulase negative staphylococcus were common, accounted for 10.1%, 5.1%, respectively. Fungi accounted for 9.5%, in which Candida were the majority. In these isolated pathogenic bacteria, gram-negative bacterial were sensitive to carbapenems,piperacillin/tazobactam and amikacin. The sensitivity rate of gram-positive bacteria to glycopeptides antibiotics were high. Candida were sensitive to common antifungal agents.Conclusion Enterobacteriaceae was the major pathogens causing urinary tract infection,and had higher degree of drug resistance rate. Etiological examination and drug sensitivity test of pathogens of urine should be performed before initiation antibiotics treatment for urinary tract infection, so as to guide the reasonable use of antibiotics and reduce the generation and dissemination of drug-resistant. |
| Key words: Grass-roots hospital Urinary tract infection Pathogens Drug resistance |
