| 摘要: |
| ［摘要］ 目的 探讨Th22和IL-22在肝细胞癌外周血的表达情况，并分析其与肿瘤标记物的相关性。方法 抽取45例肝细胞癌患者和15名正常人的外周血标本，采用流式细胞术检查Th22细胞水平，ELISA法检测IL-22水平，分析Th22、IL-22水平与肿瘤标记物AFP、CA125、CA193、CA199、CEA的相关性。结果 肝细胞癌患者Th22和IL-22水平均显著高于健康人群水平(P<0.05)。男性和女性患者Th22、IL-22水平差异无统计学意义（P>0.05）。肝细胞癌患者外周血Th22细胞数量和血清IL-22水平存在正相关(r=0.322,P=0.033)，而Th22数量和血清IL-22水平与肿瘤标记物AFP、CA125、CA193、CA199、CEA均无相关性(P>0.05)。结论 尽管Th22和IL-22在肝癌外周血中高表达，但与血清肿瘤标记物无相关性，其在肝癌发病中的临床意义仍需临床大样本研究证实。 |
| 关键词: Th22细胞 IL-22 肝癌 肿瘤标记物 外周血 |
| DOI：10.3969/j.issn.1674-3806.2014.04.01 |
| 分类号:R 735 |
| 基金项目:国家自然科学基金资助项目(编号：81260083;31360221) |
|
| Relevance of Th22 cells and IL-22 expression with tumor markers in peripheral blood of patients with hepatocellular carcinoma |
|
MA Shi-jia, GUO Xiao-yun, TAO Lin, et al.
|
|
Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021,Chnia
|
| Abstract: |
| ［Abstract］ Objective To investigate the level of Th22 cells and IL-22 in peripheral blood of patients with hepatocellular carcinoma(HCC) and their correlation with tumor markers.Methods Th22 cells in blood samples from 45 patients with HCC and 15 normal controls were detected by flow cytometry(FCM). IL-22 levels were detected by an enzyme-linked immunosorbent assay. Statistical analysis of the relevance of Th22 cells, IL-22 levels and tumor markers including AFP, CA125, CA193, CA199, CEA was performed.Results The level of Th22 cells and IL-22 in peripheral blood of patients with primary hepatic carcinoma were significantly higher than that of normal controls(P<0.05), but no significant between male and female group. The percentage of Th22 cells in HCC patients had positive correlation with the level of IL-22. Th22 cells, IL-22 levels had no correlation with tumor markers including AFP, CA125, CA193, CA199, CEA(P>0.05).Conclusion The levels of Th22 cells and IL-22 expression in peripheral blood of HCC patients are high but have no correlation with tumor markers and their clinical significance in HCC still need large clinical sample analysis. |
| Key words: Th22 cells IL-22 HCC Tumor markers Peripheral blood |
