| 摘要: |
| ［摘要］ 研究表明，红藻氨酸受体（KARs）在神经退行性变疾病中起着重要作用。兴奋性神经递质的过度活化KARs可引起该受体的过度表达，从而使神经细胞死亡。研究KARs的作用机制，可为临床治疗神经退行性变疾病提供治疗的靶点。 |
| 关键词: 红藻氨酸受体 神经兴奋毒性 神经退行性变疾病 癫痫 基因治疗 |
| DOI：10.3969/j.issn.1674-3806.2014.04.33 |
| 分类号:R 741 |
| 基金项目:国家自然科学基金资助项目（编号：81171136）；湖南省大学生研究性学习和创新性实验计划项目（编号：湘教通［2013］191号-431）；湖南省高等学校“十二五”重点学科专项建设项目（编号：湘教发［2011］76号） |
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| Research progress of relationship between kainate receptors and neurodegenerative diseases |
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YUAN Lei, GONG Ji-qin, ZHANG Hai-xia, et al.
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Changsha Medical University, Hunan 410219, China
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| Abstract: |
| ［Abstract］ Studies have shown that the kainate receptors(KARs) plays a very important role in neurodegenerative diseases.The excitatory neurotransmitters can cause up-regulation of KARs expression and neuronal cell death through excessive activation of KARs.Studying the mechanism of action of KARs can provide treatment target for neurodegenerative diseases. |
| Key words: Kainate receptors(KARs) Excitotoxicity Neurodegenerative diseases Epilepsy Gene therapy |
