| 摘要: |
| ［摘要］ 目的 探讨肿瘤细胞减灭术（CRS）加腹腔热灌注化疗（HIPEC）治疗结直肠癌腹膜转移癌(CRC PC)的疗效及安全性。方法 选取结直肠癌腹膜转移癌（CRC PC）患者67例，随机分为治疗组（CRS+HIPEC）38例，对照组（CRS+静脉辅助化疗）29例，比较两组的生存期、生存率、术后并发症及化疗毒副作用。结果 治疗组中位生存期23.0个月，显著长于对照组的11.0个月（P<0.01），治疗组1、2、3年生存率分别为70.9%、45.7%、8.2%，分别优于对照组的68.8%、21.2%、0%。术后并发症发生率两组相似（P>0.05）。化疗毒副作用：对照组恶心呕吐、白细胞减少、血小板减少发生率较治疗组高（P<0.01）,而治疗组腹胀、腹泻发生率较对照组高（P<0.01或P<0.05）；两组其他毒副作用相似（P>0.05）。结论 CRS+HIPEC治疗CRC PC能明显延长患者生存期，并发症和化疗毒副作用并没有明显增加。 |
| 关键词: 结直肠癌 腹膜转移癌 肿瘤细胞减灭术 腹腔热灌注化疗 |
| DOI：10.3969/j.issn.1674-3806.2014.07.10 |
| 分类号:R 735 |
| 基金项目: |
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| Clinical study of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy in treating patients with peritoneal carcinomatosis from colorectal cancer |
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WEI Shi-zhuang,LIU Jin-xin,FENG Guan-rong,et al.
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Department of General Surgery, the First People′s Hospital of Nanning, Guangxi 530022, China
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| Abstract: |
| ［Abstract］ Objective To evaluate the efficacy and safety of cytoreductive surgery(CRS) combined with hyperthermic intraperitoneal chemotherapy(HIPEC) in treating patients with peritoneal carcinomatosis(PC) from colorectal cancer(CRC).Methods A total of 67 CRC PC were divided into two group: therapeutics group(n=38, CRS+HIPEC) and control group(n=29, CRS and systemic adjuvant chemotherapy).Overall median survival,survival rate, adverse reaction were compared.Results Therapeutic group had a significantly better overall median survival when compared to control group(23.0 months vs. 11.0 months)（P<0.01). The 1-, 2- and 3- year survival rate of therapeutic group were 70.9%,45.7% and 8.2%, respectively, superior to those of control group(68.8%,21.2% and 0%).Two group had a similar postoperative complication rate(P>0.05). Chemotherapy toxic effects:control group had higher incidence rate in nausea and vomiting, leucopenia, thrombocytopenia(P<0.01) while therapeutic group higher in abdominal distension and diarrhea(P<0.01 or P<0.05). Two group had similar incidence rate in hypoproteinemia, hepatic and renal insufficiency, respiratory tract infections, hyperbilirubinemia(P>0.05).Conclusion The CRS+HIPEC method can greatly improve the survival of patients with PC from CRC while doesn′t significantly increase postoperative complication rate and chemotherapy toxic effects. |
| Key words: Colorectal cancer Peritoneal carcinomatosis Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy |
