| 摘要: |
| ［摘要］ 目的 观察不同剂量阿托伐他汀对老年早期糖尿病肾病（DN）患者外周血单个核细胞中核因子-κB（NF-κB）P65(ser536)的磷酸化水平、血清炎症因子水平（hs-CRP、TNF-α、IL-6、IL-1β）及尿白蛋白排泄率（UAER）的影响。方法 将72例2型糖尿病早期DN老年患者，半随机分为两组，分别给予阿托伐他汀钙片10 mg/d（DN1组，37例）和20 mg/d（DN2组，35例）,疗程16周。测定两组患者治疗前和治疗16周后外周血NF-κB P65的磷酸化水平、血清炎症因子水平、UAEA、血脂（TC、TG、DHL-C、LDL-C）。结果 两组患者治疗后外周血NF-κB P65水平、血清炎症因子水平、TC及LDL-C均较治疗前降低(P<0.01或P<0.05)，以DN2组降低更显著。DN2组治疗后UAER较治疗前显著降低（P<0.01）,DN1组无显著下降（P>0.05）。结论 阿托伐他汀在降低血脂的同时可降低外周血NF-κB P65的活性、血清炎症因子hs-CRP、TNF-α、IL-6、IL-1β水平，改善患者炎症状态，减少尿蛋白，且呈剂量依赖性。 |
| 关键词: 糖尿病肾病 核因子κB 炎症因子 尿白蛋白排泄率 阿托伐他汀 |
| DOI：10.3969/j.issn.1674-3806.2014.09.01 |
| 分类号:R 587.1 |
| 基金项目:广西科学研究与技术开发计划课题（编号：桂科攻11138008） |
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| Effects of different doses of atorvastatin on the activity of nuclear factor-kappa B in peripheral blood mononuclear cells and urinary albumin excretion rate in the elderly patients with early diabetic nephropathy |
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LI Jian-ying, GUO Jin, TAN Wen-fang, et al.
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The Second Area of Cadre Integrated Ward, the People′s Hospital of Guanxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To observe the effects of different doses of atorvastatin on phosphorylation of nuclear factor-kappa B(NF-κB) P65(ser536) in peripheral blood mononuclear cells, on the levels of serum inflammatory factors，including high sensitivity C reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)，interleukin-1β(IL-1β), and on urinary albumin excretion rate(UAER) in the elderly patients with early diabetic nephropathy.Methods The patients(n=72) of type 2 diabetes with early nephropathy were randomly divided into two groups,The patients were given atorvastatin 10 mg/d in DN1 group and atorvastatin 20 mg/d in DN2 group for sixteen weeks. Levels of NF- κB, serum inflammation factors,UAER，Total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL-C) and hight density lipoprotein(HDL-C) were measured before treatment and after treatment for sixteen weeks.Results After sixteen weeks of treatment, the levels of NF-kB, serum inflammation factors, TC and LDL were reduced(P<0.05 or P<0.01) in two group. DN2 group decreased more significantly. UAER were reduced(P<0.01)in DN2 group. There was no significant changes in DN1 group(P>0.05).Conclusion Atorvastatin can reduce activity of NF-κB, levels of hs-CRP,TNF-α,IL-6,IL-1β,TC, and LDL in the olderly patients with type 2 diabetic pristine nephropathy. Atorvastatin may benefit patients with diabetes mellitus by ameliorating inflammatory stats, as well as reducing urinary albumin,in a dose-dependent manner. |
| Key words: Diabetic nephropathy(DN) NF-κB Inflammation factors Urinary albumin excretion rate(UAER) Atorvastatin |
