| 摘要: |
| ［摘要］ 目的 探讨冠心病（CHD）患者血清中同型半胱氨酸（HCY）、胱抑素C（CysC）、N-末端脑利钠肽前体（NT-proBNP）水平变化及临床意义。方法 应用日立7100全自动生化分析仪及FIA8000免疫分析仪，分别检测52例冠心病患者和52名健康体检者血清中HCY、CysC及NT-proBNP的含量，并对结果进行统计学分析。结果 冠心病患者血清中HCY、CysC及NT-proBNP含量均显著高于健康体检者，两者差异具有统计学意义（P<0.01）；心肌梗死组与无心肌梗死组HCY、NT-proBNP水平两者比较差异具有统计学意义（P<0.05或P<0.01），CysC含量两者之间差异无统计学意义(P>0.05)。结论 联合检测血清中HCY、CysC及NT-proBNP水平，对临床诊断与治疗冠心病具有一定的指导意义。 |
| 关键词: 冠心病（CHD） 同型半胱氨酸（HCY） 胱抑素C（CysC） N-末端脑利钠肽前体（NT-proBNP） |
| DOI：10.3969/j.issn.1674-3806.2014.09.12 |
| 分类号:R 44 |
| 基金项目: |
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| Variation and clinical significance of serum homocysteine and Cystatin C and N-terminal probrain natriuretic peptide precursor in patients with coronary heart diseas |
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HUANG Xin-gen, ZENG Fang-lan, WU Mei-xiang
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Department of Laboratory, the People′s Hospital of Xiajiang County, Jiangxi 331409, China
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| Abstract: |
| ［Abstract］ Objective To investigate the changes of serum homocysteine(HCY)，cystatin C(CysC) and N-terminal probrain natriuretic peptide precursor(NT-proBNP) in patients with coronary heart disease and its clinical significance.Methods Hitachi 7100 automatic biochemical analyzer and FIA8000 immunoassay analyzer were used to detect serum levels of HCY, CysC and NT-proBNP in 52 cases of coronary heart disease patients and 52 cases of healthy volunteers, and the results were statistically analyzed.Results Content of serum HCY and CysC and NT-proBNP in patients with coronary heart disease were significantly higher than those in healthy individuals(all P<0.01). Between myocardial infarction group and no myocardial infarction group there were a statistically significant difference in level of Hcy and NT-proBNP(P<0.05 or P<0.01),but there was no statistical significance in level of CysC(P>0.05).Conclusion Combined detection of serum HCY, CysC and NT-proBNP levels, has a ceitain guiding significance for clinical diagnosis and treatment of coronary heart disease. |
| Key words: Coronary heart disease(CHD) Homocysteine(HCY) Cystatin C(CysC) N-terminal probrain natriuretic peptide precursor(NT-proBNP) |
