| 摘要: |
| ［摘要］ microRNA(miRNA)是一类长约18～25个核苷酸的小分子非编码RNA，它通过与靶基因3＇端非翻译序列结合促进靶基因降解或抑制翻译过程，从而抑制靶基因表达。最近研究表明，miRNA在血管和心脏中高度表达，参与调节心脏发育、心律失常、高血压、心肌梗死、心力衰竭等心血管生理病理过程。该文回顾总结有关miRNA在急性心肌梗死诊断及预后中的研究进展。 |
| 关键词: microRNA 心血管疾病 急性心肌梗死 |
| DOI：10.3969/j.issn.1674-3806.2014.09.31 |
| 分类号:R 54 |
| 基金项目: |
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| Research progress of microRNA in diagnosis and prognosis of acute myocardial infarction |
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GONG Guo-ping, WANG Hong
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Guangxi University of Traditional Chinese Medicine, Nanning 530021, China
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| Abstract: |
| ［Abstract］ microRNA（miRNA）are small non-coding RNAs of 18～25 nucleotides，which can negatively regulate the gene expression at post-transcriptional level by interacting with complementary sites in the 3′untranslated sequences of the target gene.Recent studies have identified that miRNAs are highly expressed in vasculature and heart，participate in the regulation of cardiac development, arrhythmia, hypertension, myocardial infarction, heart failure and other cardiovascular physiology and pathology process. Here is to make a review on the research progress regarding the roles of miRNAs in acute myocardial infarction. |
| Key words: microRNA(miRNA) Cardiovascular diseases Acute myocardial infarction |
