| 摘要: |
| ［摘要］ 目的 了解该院门诊和住院双膦酸盐类药物的使用情况，探讨双膦酸盐类药物处方专项点评的工作模式和方法。方法 回顾性抽取该院2013-04～2014-03双膦酸盐类药物全部门诊处方和住院医嘱，对双膦酸盐类药物各品种的处方使用率进行统计分析；并逐张处方进行用药合理性点评，对不适宜处方进行问题分类统计分析。结果 该院门诊2013-04～2014-03双膦酸盐类药物处方共计3 080张，其中唑来膦酸1 594张(51.75%)和阿仑膦酸1 341张（43.54%）为门诊应用最多的双膦酸盐类药物。相关科室住院病历中使用双膦酸盐类药物共计2 958人次，住院使用率为19.95%，其中以唑来膦酸1 585张(63.72%)和帕米膦酸二钠856张(25.56%)为临床应用最为广泛。专项处方点评辨识出不适宜处方689张，占全部用药处方和医嘱的11.67%。处方问题涉及适应证不适宜186张(27.00%)、用法用量不适宜310张(44.99%)、溶媒选择不适宜24张（3.48%）、配伍不适宜135张(19.59%)、其他不适宜34张（4.93%）。结论 该院双膦酸盐类药物处方和医嘱用药仍存在不适宜问题。开展专项处方点评工作有助于发现用药典型问题，为合理用药干预和持续改进提供参考。 |
| 关键词: 双膦酸盐类药物 处方点评 合理用药 不适宜处方 |
| DOI：10.3969/j.issn.1674-3806.2015.02.08 |
| 分类号:R92 |
| 基金项目: |
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| Practice in special prescription evaluation of bisphosphonates agent |
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CHEN Ying, XI Jia-xi, YE Dong-mei
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Department of Pharmacy, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the utilization of bisphosphonates agents in outpatients and inpatients of the People′s Hospital of Guangxi Zhuang Autonomous Region, and explore work model and method of special prescription evaluation.Methods All the electronical prescriptions of bisphosphonates agents of the outpatients and inpatients from April 2013 to March 2014 were analyzed retrospectively.The prescription rate and structure ratio of bisphosphonates agents were calculated.By setting the bisphosphonates agents prescription evaluating standard,the medication rationality of each sample prescription was evaluated and inappropriate prescriptions were classified and analyzed.Results 3 080 bisphosphonates agents prescriptions were collected from outpatients from April 2013 to March 2014 in which zoledronic acid(the prescription rate of 51.75%) and alendronic acid(the prescription rate of 43.54%) were used mostly. 2 958 bisphosphonates agents prescriptions were collected from inpatients from April 2013 to March 2014 in which zoledronic acid(the prescription rate of 63.72%) and pamidronate disodium(the prescription rate of 25.56%) were used mostly. 689 inappropriate prescriptions accounted for 11.67% of the bisphosphonates agent prescriptions.The inappropriate prescriptions were related to inappropriate indication(27.00%),inappropriate usage and dosage(44.99%),drug interaction(19.59%)and other inappropriate prescriptions(8.42%).Conclusion The practice in special prescription evaluation is helpful to discover some typical inappropriate medications in the prescriptions, which is supposed to provide scientific evidence for intervention and continuous improvement of rational medication. |
| Key words: Bisphosphonates agent Prescription evaluation Rational medication Inappropriate prescription |
