| 摘要: |
| ［摘要］ 目的 探讨2型糖尿病患者颈动脉粥样硬化斑块与血糖波动的关系。方法 选择2型糖尿病患者198例，根据颈动脉彩色多普勒超声显像分为无颈动脉硬化组53例(A组)、颈动脉粥样硬化稳定斑块组68例（B组）、颈动脉粥样硬化不稳定斑块组77例（C组）。三组均采用动态血糖监测系统(CGMS)连续监测72 h血糖，计算平均血糖水平(MBG)、日内平均血糖波动幅度(MAGE)，并记录血压、糖化血红蛋白（HbA1c）、血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等指标的监测结果。结果 三组收缩压、舒张压、FPG、TC、HDL-C、LDL-C、HbA1c比较差异有统计学意义(P<0.05或P<0.01)，MBG、MAGE随颈动脉粥样硬化程度逐渐增高(P<0.01)。结论 2型糖尿病患者血糖波动会增加颈动脉粥样硬化斑块风险，需重视动态血糖监测。 |
| 关键词: 2型糖尿病 血糖波动 动态血糖监测 颈动脉内膜-中膜厚度 粥样硬化斑块 |
| DOI：10.3969/j.issn.1674-3806.2015.04.10 |
| 分类号:R 587.1 |
| 基金项目: |
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| Ultrasonic evaluation on the relationship between carotid atherosclerotic plaques and blood glucose fluctuation in patients with type 2 diabetes |
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TAN Jie-lin
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Department of Ultrasound, the People′s Hospital of Liuzhou City, Guangxi 545006, China
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| Abstract: |
| ［Abstract］ Objective To study the relationship between the carotid atherosclerotic plaque and blood glucose fluctuations in patients with type 2 diabetes(T2DM).Methods According to the carotid artery color doppler ultrasonography, 198 patients with T2DM were divided into no carotid sclerosis group(group A, n=53), the stable carotid atherosclerosis plaque group(group B, n=68), and unstable carotid atherosclerosis plaque group(group C, n=77). Dynamic glucose monitoring system(CGMS) was used to continuously monitor 72 h blood sugar, calculate the mean blood glucose(MBG), within-day mean amplitude of glycemic excursion(MAGE), and recorded the age, blood pressure, glycated hemoglobin(HbA1c), serum total cholesterol(TC), triglycerides(TG), low-density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), and gender.Results Among the three groups, there were statistically significant differences in systolic pressure, diastolic blood pressure, FPG, TC, HDL-C, LDL-C and HbA1c, and MBG, MAGE gradually increased with the degree of carotid artery atherosclerosis(all P<0.05).Conclusion In patients with T2DM, the blood sugar fluctuation increases the risk of carotid atherosclerotic plaques, therefore the dynamic blood sugar monitoring should be paid attention to. |
| Key words: Type 2 diabetes(T2DM) Blood glucose fluctuation Dynamic blood sugar monitoring Carotid intima - media thickness Atherosclerotic plaques |
