| 摘要: |
| ［摘要］ 目的 了解金黄色葡萄球菌感染的特点及其对抗菌药物的耐药性，为临床治疗金黄色葡萄球菌感染提供选药依据。方法 对2012-01～2014-06该院临床分离出的196株金黄色葡萄球菌进行常规培养分离鉴定，药敏试验应用K-B纸片扩散法，按国家临床实验室标准委员会/美国临床实验室准化委员会（CLSI/NCCLS）规定的标准进行细菌鉴定和药敏检测。结果 共分离出耐甲氧西林金黄色葡萄球菌（MRSA）91株（46.4%），甲氧西林敏感金黄色葡萄球菌（MSSA）105株（53.6%）。其中MRSA主要来源于呼吸内科，以老年患者为主。MRSA及MSSA对万古霉素、利奈唑胺、替考拉宁均敏感。MRSA对氨苄西林、苯唑西林、青霉素G、头孢唑林、头孢西丁的耐药率为100%，MSSA耐药率由高至低依次为青霉素G、氨苄西林、红霉素。MRSA对各种抗菌药物的耐药率均高于MSSA，差异有统计学意义（P<0.01）。结论 MSSA和MRSA对抗菌药物耐药率不同，须重视金黄色葡萄球菌的耐药监测，控制耐药菌株，更好地指导临床合理选用抗生素。 |
| 关键词: 金黄色葡萄球菌 耐甲氧西林金黄色葡萄球菌 药敏试验 耐药性 |
| DOI：10.3969/j.issn.1674-3806.2015.04.19 |
| 分类号:R 446 |
| 基金项目: |
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| Research on nosocomial infection and drug resistance of staphylococcus aureus |
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JIANG Li-li
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Department of Laboratory, the Dachang Hospital of Nandan County, Guangxi 547200, China
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| Abstract: |
| ［Abstract］ Objective To study the nosocomial infection features and drug resistance of Staphylococcus aureus and provide a clinical evidence of antibiotics selection.Methods The isolated bacteria were identified and antibiotic sensitivity was detected using K-B disk diffusion method according to standard CLSI /NCCLS requirement in 196 strains of Staphylococcus aureus collected in Dachang hospital of Nandan county from January 2012 to June 2014.Results In 196 strains of Staphylococcus aureus, methicillin-resistant Staphylococcus aureus(MRSA) accounted for 46.4%(91/196), the methicillin sensitive staphylococcus aureus(MSSA) accounted for 53.6%(105/196). Most of MRSA infections were found in elderly patients in respiratory department. The sensitivity rate of both MRSA and MSSA to vancomycin, linezolid and teicoplanin was 100.0%. The resistance rate of MRSA to ampicillin, oxacillin, penicillin, cefazolin, cefoxitin was 100.0%. The resistant rate of MSSA to penicillin, ampicillin, erythromycin was decreased successively. The drug resistant rate of MRSA to antibiotics was higher than that of MSSA(P<0.05).Conclusion The drug resistance of MSSA and MRSA to antibiotics was different. The monitoring drug resistance of MRSA should be further strengthened clinically in order to control the drug resistant strains and reasonably use antimicrobial drugs. |
| Key words: Staphylococcus aureus Methicillin-resistant staphylococcus aureus(MRSA) Drug sensitivity test Drug resistance |
