| 摘要: |
| ［摘要］ 乙肝病毒是一种嗜肝DNA病毒,当病毒侵入机体后,由于机体对乙肝病毒及其表达产物的免疫应答导致肝细胞损伤，并激发自身免疫反应及免疫调节功能的紊乱，而引起乙型病毒性肝炎。Toll样受体9（TLR9）作为一种主要识别细菌或病毒非甲基化CpGDNA的重要的模式识别受体,与乙型病毒性肝炎的发生、发展、治疗及预后密切相关。该文就TLR9及其与乙型病毒性肝炎的研究进展进行综述。 |
| 关键词: Toll样受体9 乙肝病毒 免疫应答 受体 研究进展 |
| DOI：10.3969/j.issn.1674-3806.2015.06.33 |
| 分类号:R 512.6+2 |
| 基金项目: |
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| Research progress on TLR9 and its correlation with hepatitis B virus |
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REN Rong, MAO Xue-feng, TAN Yi
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Department of Laboratory, Yulin Central Blood Station, Guangxi 537000, China
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| Abstract: |
| ［Abstract］ Hepatitis B virus(HBV) is a hepadnavirus DNA virus. When the virus invades the body,it could cause HBV, because the immune response of body to HBV and its expression products would lead to liver cell damage and further stimulate body immune response with disturbance of immune regulatory function. TLR9 is an important pattern recognition receptor which generally recognizes bacterial or viral unmethylated CpGDNA, and it is closely related to the onset, treament and prognosis of patients with HBV. We review the research progress of TLR9 and its correlation with HBV in this paper. |
| Key words: Toll-like receptor-9(TLR9) Hepatitis B virus(HBV) Immune response Receptor Research progress |
