| 摘要: |
| ［摘要］ 目的 观察异甘草酸镁联合还原型谷胱甘肽治疗老年药物性肝损伤的疗效。方法 选择66例老年药物性肝损伤患者随机分为两组，每组33例，对照组给予异甘草酸镁100 mg，治疗组给予异甘草酸镁100 mg+还原型谷胱甘肽1.2 g，两组均加入5%葡萄糖100 ml(或0.9%生理盐水100 ml)静脉滴注，1次/d，连用15 d。观察比较两组丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、总胆红素（TBIL）、γ-谷氨酰转移酶（GGT）、碱性磷酸酶（ALP）等指标治疗前后的变化情况。结果 治疗组较对照组在恢复肝脏功能方面疗效较好，两组比较差异有统计学意义(P<0.05)。结论 异甘草酸镁联合还原型谷胱甘肽治疗老年药物性肝损伤疗效较好。 |
| 关键词: 异甘草酸镁 还原型谷胱甘肽 老年人 药物性肝损伤 |
| DOI：10.3969/j.issn.1674-3806.2016.01.12 |
| 分类号:R 575 |
| 基金项目: |
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| Clinical study of isoglycyrrhizinate magnesium combined with reduced glutathione on drug-induced liver injury in elderly patients |
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ZHOU Xiao-ping, ZHOU Xin-ming
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Department of Internal Medicine, Fogang County Hospital of Traditional Chinese Medicine, Guangdong 511600, China
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| Abstract: |
| ［Abstract］ Objective To study the effect of isoglycyrrhizinate magnesium combined with reduced glutathione on drug-induced liver injury in elderly patients.Methods Sixty-six elderly patients with drug-induced liver injury were randomly divided into two groups, with 33 cases in each group. The control group was given isoglycyrrhizinate magnesium 100 mg and the treatment group was given isoglycyrrhizinate magnesium 100 mg+reduced glutathione 1.2 g, 5%GS 100 ml(or 0.9%NS 100 ml) for intravenous drip, qd×15 days. Alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBIL), γ- glutamyl transferase(GGT) and alkaline phosphatase(ALP) were detected.Results The treatment group was more effective in restoring liver function than the control group(P<0.05).Conclusion Isoglycyrrhizinate magnesium combined with reduced glutathione is effective in the treatment of drug-induced liver injury in elderly patients. |
| Key words: Isoglycyrrhizinate magnesium Reduced glutathione Elderly patients Drug-induced liver injury |
