| 摘要: |
| ［摘要］ 目的 为掌握广西地区成人社区获得性肺炎（CAP）的病原学构成情况，比较广西农村和城市CAP的病原学构成特点，推进广西地区CAP的规范化诊疗。方法 收集2008-01～2010-12广西14所县市级医院的889例CAP患者，进行病原学调查，并根据地域分为城市地区（城市组331例）和农村地区（农村组578例），比较病原学构成比差异。结果 研究期CAP病例中阳性422例患者入选，共检出486株病原菌，前五位的病原菌为肺炎支原体（138/486，28.40%）、流感嗜血杆菌（88/486，18.11%）、肺炎链球菌（77/486，15.84%）、肺炎克雷伯杆菌（53/486，10.91%）和肺炎衣原体（43/486，8.94%）。农村组肺炎支原体、铜绿假单胞菌感染的CAP比例高于城市组（41.12% vs 19.72%和5.58% vs 1.73%），而肺炎链球菌、嗜肺军团菌感染低于城市组（8.1% vs 21.11%和3.05% vs 7.96%）。城市组细菌（除外嗜肺军团菌）多见（183例，占63.3%），农村组则以非典型病原体多见（104例，占52.8%）。结论 广西成人CAP病原学以肺炎支原体最常见，流感嗜血杆菌和肺炎链球菌也是常见菌群。广西农村地区以非典型病原菌为主，城市则以细菌常见。 |
| 关键词: 社区获得性肺炎 病原学 流行病学 |
| DOI：10.3969/j.issn.1674-3806.2016.02.04 |
| 分类号:R 563.1 |
| 基金项目:广西科学研究与技术开发计划课题（编号：桂科攻0816004-9） |
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| A multicenter investigation on the etiology in 889 adult patients with community-acquired pneumonia in Guangxi Zhuang Autonomous Region |
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JIANG Ling-yu, QIN Zhi-qiang, GAO Xing-hua, et al.
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Department of Respiratory Medicine, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the etiologic characteristics of the adult patients with community-acquired pneumonia(CAP) in the urban and rural areas of Guangxi Zhuang Autonomous Region, and facilitate the development of normalized diagnosis and treatment of CAP.Methods A prospective study was performed on 889 adult patients with CAP at 14 centers in Guangxi Zhuang Autonomous Region from January 2008 to December 2010. All the patients were divided into urban area group and rural area group according to the different geography distributions. The etiologic characteristics and the distribution of detected pathogens were compared between the two groups.Results 486 strains of pathogens were isolated from 422 patients with qualified serum samples and/or sputum cultures, including Mycoplasma pneumoniae(138/486,28.40%), Haemophilus infulenzae(88/486,18.11%), Streptococcus pneumoniae(77/486, 15.84%), Klebsiella pneumoniae(53/486,10.91%) and Chlamydia pneumoniae(43/486,8.94%). Mycoplasma pneumonia infection and Pseudomonas aeruginosa infection were higher in the population of the rural area group than those in the urban area group(41.12% vs 19.72% and 5.58% vs 1.73%), while the proportions of Streptococcus pneumoniae infection and legionella pneumophila infection were lower in the rural area group than those in the urban area group(8.1% vs 21.11% and 3.05% vs 7.96%). In the CAP patients, bacteria(excluding legionella pneumophila) were responsible for the infection in the urban group, and atypical pathogens were responsible for the infection in the rural group.Conclusion Mycoplasma pneumoniae is the most common pathogen that leads to adult CAP in Guangxi Zhuang Autonomous Region. Haemophilus infulenzae and Streptococcus pneumoniae are still the most popular pathogenic bacteria for CAP as well. Atypical pathogens are the most common pathogens in the urban areas but bacteria in the rural areas. |
| Key words: Communityacquired pheumonia(CAP) Pathogens Epidemiology |
