| 摘要: |
| ［摘要］ 目的 探讨生精胶囊及左卡尼汀对不育症患者精子DNA断裂指数（DFI）、精子顶体完整率及行体外受精结局的影响。方法 选取来该中心就诊的322对不育症患者，分别用生精胶囊（A组）96例、左卡尼汀103例（B组）、生精胶囊联合左卡尼汀123例（C组）治疗3个月后行体外受精-胚胎移植，并常规检查精子顶体完整率及DFI。结果 （1）治疗后C组患者的精子DNA完整率、精子顶体完整率、受精率、优胚率均显著高于A、B两组（P<0.05）；（2）三组卵裂率差异无统计学意义（P>0.05）。（3）A组精子顶体完整率、受精率、优胚率均显著高于B组（P<0.05），A、B两组精子DNA完整率差异无统计学意义（P>0.05）。（4）临床妊娠率C组>A组>B组，分别为51.2%、45.8%、39.8%（P>0.05）。结论 生精胶囊治疗不育症患者精子顶体完整率、优胚率、临床妊娠率优于左卡尼汀，生精胶囊联合左卡尼汀治疗后精子DNA完整率、精子顶体完整率、受精率、优胚率、临床妊娠率均优于单独使用生精胶囊或左卡尼汀。 |
| 关键词: 生精胶囊 左卡尼汀 体外受精 DNA断裂指数（DFI） 精子顶体完整率 |
| DOI：10.3969/j.issn.1674-3806.2016.04.01 |
| 分类号:R 698+.2 |
| 基金项目:国家自然科学基金资助项目（编号：81360107）;广西医疗卫生适宜技术研究与开发课题（编号：S201421-03） |
|
| The effects of Shengjing capsules in combination with Levocarnitine on DNA and acrosome intact rate of sperms and outcomes in vitro fertilization cycles |
|
HE Yong-zhi, LI Da-wen, HE Bing, et al.
|
|
Reproductive Medicine Center, the Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region, Nanning 530003, China
|
| Abstract: |
| ［Abstract］ Objective To explore the effects of Shengjing capsules in combination with Levocarnitine on DNA fragmentation index(DFI) and acrosome intact rate of sperms and outcomes in vitro fertilization cycles.Methods The DFI, acrosome intact rate and clinical outcomes of 322 infertility male patients were analysed retrospectively according to the different treatment protocals. Group A(n=96) was treated with Shengjing capsules, and group B(n=103) received Levocarnitine. Group C（n=123） was given Shengjing capsules combined with Levocarnitine. The three groups were performed in vitro fertilization(IVF) three months after the treatment.Results (1)The sperm DNA integrity rate, sperm acrosome intact rate, fertilization rate, good-quality embryo rate and the clinical pregnancy rate in group C were significantly higher than those in group A and group B(P<0.05).（2)There were no significant differences in the cleavage rates among the three groups(P>0.05). (3)The sperm acrosome intact rate, fertilization rate, good-quality embryo rate, clinical pregnancy rate in group A were significantly higher than those in group B(P<0.05). There was no significant difference in sperm DNA integrity rate between group A and group B(P>0.05).（4）The clinical pregnancy rate was 51.2%, 45.8% and 39.8% in group C, group B and group A respectively(P>0.05).Conclusion Sperm acrosome intact rate, good-quality embryo rate and clinical pregnancy rate in infertility male patients treated with Shengjing capsules were improved better than those with Levocarnitine; the sperm DNA integrity rate, acrosome intact rate, fertilization rate, good-quality embryo rate and clinical pregnancy rate were improved better in the patients treated with Shengjing capsules in combination with Levocarnitine than those with Shengjing capsules or Levocarnitine. |
| Key words: Shengjing capsule Levocarnitine In vitro fertilization DFI Sperm acrosome intact rate |
