| 摘要: |
| ［摘要］ 目的 探讨胃肠道间质瘤（gastrointestinal stromal tumor,GIST）的临床特点、诊断和治疗方法。方法 回顾性分析该院2004-06～2014-06收治的30例GIST患者的临床资料。 结果 GIST病变部位为胃14例，十二指肠2例，小肠10例，结肠2例，直肠2例。30例均在术前通过影像学检查明确病灶部位。全部病例均行手术切除，其中行联合脏器切除2例，内镜下切除3例。术后均由病理学检查及免疫组织化学检测确诊。酪氨酸激酶受体（CD117）阳性率为96.7%(29/30)，DOG-1阳性率为93.3%(28/30)，骨髓干细胞抗原（CD34）阳性率为73.3%(22/30)。有效随访25例,随访12个月～10年，8例死亡，8例复发转移，9例病情稳定。结论 GIST的临床表现无特异性，提高对GIST的认识，减少误诊，积极的手术切除结合靶向治疗是改善其预后的主要措施。 |
| 关键词: 胃肠道间质瘤 诊断 外科手术 靶向治疗 |
| DOI：10.3969/j.issn.1674-3806.2016.04.07 |
| 分类号:R 735 |
| 基金项目: |
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| Diagnosis and surgical treatment of gastrointestinal stromal tumor: a report of 30 cases |
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HUANG Peng, WU He-shui
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Department of General Surgery, the Fourteenth Hospital of Wuhan City, Hubei 430200, China
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| Abstract: |
| ［Abstract］ Objective To explore the clinical characteristics，diagnosis and treatment of gastrointestinal stromal tumor（GIST）.Methods The clinical data of 30 patients with GIST who were admitted between June 2004 and June 2014 were analyzed retrospectively.Results In the 30 patients with GIST, the lesions were located in the stomach（14 cases）, duodenum（2 cases）, small intestine（10 cases）, colon（2 cases） and rectum（2 cases）. All the lesions were identified by imaging examination. All patients underwent complete resections, including multiple organs resection(2 cases) and endoscopic resection(3 cases). After the operation, the diagnosis was confirmed by pathological examination and immunohistochemistry. The results of immunohistochemistry demonstrated that tumor cells were positive for CD117 in 29 cases(96.7%), for CD34 in 22 cases(73.3%) and for DOG-1 in 28 cases(93.3%). Twenty-five patients were followed up postoperatively from 12 months to 10 years. During the follow-up period, 8 cases died, recurrence or metastasis occurred in 8 cases, and 9 cases remained in a stable condition.Conclusion GIST shows untypical clinical features. Raising awareness of GIST, avoiding misdiagnosis, timely surgical resection and targeted therapy are the major measures for improving the prognosis of GIST. |
| Key words: Gastrointestinal stromal tumor（GIST） Diagnosis Surgical management Targeted therapy |
