| 摘要: |
| ［摘要］ 目的 探讨磁共振动态增强成像（dynamic contrast enhanced MRI，DCE-MRI）在原发性肝癌诊断中的应用价值。方法 将39例行DCE-MRI并经病理证实的肝脏占位病变患者分为原发性肝癌组27例和非癌结节组12例。应用Tissue-4D软件进行测量分析，获得感兴趣区的组织容积灌注参数即转运常数（Ktrans）、血管外细胞外间隙体积百分比（Ve）、速率常数（Kep）。结果 两组患者Ktrans、Ve均值差异具有统计学意义，两组患者Kep均值差异无统计学意义。ROC曲线有中度诊断价值。诊断原发性肝癌Ktrans的最佳诊断阈值为0.298 min-1，敏感度为0.926，特异度为0.750。诊断原发性肝癌Ve的最佳诊断阈值为0.237，敏感度为0.926，特异度为0.500。结论 DCE-MRI可以定量分析病变的微循环情况，为鉴别原发性肝癌与非癌结节提供了一种有效的方法。 |
| 关键词: 磁共振动态增强成像 原发性肝癌 微血管通透性 组织容积灌注参数 |
| DOI：10.3969/j.issn.1674-3806.2016.05.06 |
| 分类号:R 735.7 |
| 基金项目:广西教育厅高校科研重点项目（编号：ZD2014028） |
|
| The application of dynamic contrast enhanced MRI in the diagnosis of primary hepatocellular carcinoma |
|
KONG Yuan, LI Wen-mei
|
|
Department of Radiology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
|
| Abstract: |
| ［Abstract］ Objective To study the value of dynamic contrast enhanced MRI（DCE-MRI） in the diagnosis of primary hepatocellular carcinoma.Methods Thirty-nine patients with liver local masses examined by DCE-MRI and verified by pathological findings were divided into 2 groups. The primary hepatocellular carcinoma group(n=27) and the nontumorous nodule group(n=12). Tissue-4D software was used for the post-processing of the DCE-MRI images and the tissue volume perfusion parameters including transfer constant（Ktrans）, extravascular extracellular space volume（Ve） and rate constant（Kep） were calculated.Results There were statistically significant differences in Ktrans and Ve between the two groups. The ROC curve had moderate diagnostic value. When the best diagnostic threshold of Ktrans for hepatocellular carcinoma was 0.298 min-1, the sensibility was 0.926 and the specificity was 0.750. When the best diagnostic threshold of Ve for hepatocellular carcinoma was 0.237, the sensibility was 0.926 and the specificity was 0.500.Conclusion DCE-MRI can quantificationally analyze microcirculation of the lesion. It provides an effective method for identifying benign and malignant nodules. |
| Key words: Dynamic contrast enhanced MRI Hepatocellular carcinoma Microvascular permeability Perfusion parameters of tissue |
