| 摘要: |
| ［摘要］ 膜性肾病是成人肾病综合征常见的病因之一，发病率逐年升高。膜性肾病从本质上来说属于自身免疫性疾病，其公认机制为T淋巴细胞刺激B淋巴细胞的增殖和激活，导致免疫复合物形成并沉积于肾小球基底膜上皮细胞下。外周血淋巴细胞亚群为近年的研究热点，该文从T细胞亚群和B淋巴细胞两个方面阐述特发性膜性肾病免疫学研究的新进展，为其防治提供新的靶点。 |
| 关键词: 特发性膜性肾病 免疫 T细胞亚群 B淋巴细胞 利妥昔单抗 |
| DOI：10.3969/j.issn.1674-3806.2016.05.28 |
| 分类号:R 593 |
| 基金项目:国家自然科学基金资助项目（编号：81260121） |
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| Immunological research advances of peripheral blood lymphocyte subsets in idiopathic membranous nephropathy |
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LONG Teng-xiang, YE Kun
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Department of Internal Medicine, Guangxi University of Chinese Medicine, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Membranous nephropathy is one of the common causes of adult nephritic syndrome, and its incidence has been on the rise significantly. As a kind of autoimmune disease, membranous nephropathy is generally recognized to be caused by the deposition of immune complex formation under the glomerular basement membrane epithelium as a result of B lymphocyte proliferation and activation stimulated by T lymphocytes, but its specifical pathogenesis remains unclear. Peripheral blood lymphocyte subsets become a research hotspot in recent years. This paper aims to highlight the immunological research advances of T lymphocyte subsets and B lymphocytes in idiopathicmembranous nephropathy, so as to provide a novel target for the prevention and treatment of idiopathic membranous nephropathy. |
| Key words: Idiopathic membranous nephropathy(IMN) Immunization T lymphocyte subsets B lymphocytes Rituximab |
