| 摘要: |
| ［摘要］ 人类免疫缺陷病毒1型（HIV-1）具有高度变异的特性。HIV-1有9种亚型和78种流行重组型，HIV-1亚型在全球呈不均匀分布。HIV-1亚型多样性可对病毒的传播途径和传播能力、毒力和疾病进展、药物敏感性和耐药性、疫苗研发产生影响，使艾滋病的防治形势面临着严峻的挑战。该文对其研究近况作一综述。 |
| 关键词: 人类免疫缺陷病毒 亚型 艾滋病 |
| DOI：10.3969/j.issn.1674-3806.2016.06.25 |
| 分类号:R 512.91 |
| 基金项目:国家自然科学基金项目（编号：81360258）；广西自然科学基金项目（编号：2014GXNSFAA118175） |
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| HIV-1 subtype diversity and its challenges for AIDS prevention and treatment |
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SU Qi-jian, TAN Yi
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Center for AIDS Research, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China
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| Abstract: |
| ［Abstract］ Variability is a hallmark of the human immunodeficiency virus type 1(HIV-1), which can be divided into 9 subtypes and 78 circulating recombinant forms(CRFs). HIV-1 subtypes are not evenly distributed around the world, and the diversity of HIV-1 subtypes may exert an influence on transmission routes, infectivity, virulence, disease progression, drug susceptibility, drug resistance and vaccine development and brings great challenges for AIDS prevention and treatment. The research progress of various HIV-1 subtypes is reviewed in this paper. |
| Key words: Human immunodeficiency virus(HIV) Subtype Acquired immunodeficiency disease syndrome(AIDS) |
