| 摘要: |
| ［摘要］ 目的 探讨老年动脉硬化合并糖尿病介入术后药物治疗的效果。方法 选取2010-12～2013-12收治的老年动脉硬化合并糖尿病患者78例为研究对象，均给予介入手术治疗，根据患者术后治疗方法不同分为对照组（术后给予氯吡格雷治疗）和研究组（术后给予氯吡格雷联合西洛他唑治疗），每组39例。观察两组1年后手术成功率、保肢率、症状缓解率、不良症状和血管踝臂指数（ABI）。结果 （1）78例患者介入手术成功率为100.00%，手术后1年内保肢率为93.59%。（2）研究组术后1年后截肢率、间歇性跛行率、静息痛发生率均低于对照组（P<0.05）。（3）治疗前，两组患者的ABI值差异不大，治疗1年后两组患者的ABI值均得到不同程度改善，研究组ABI值高于对照组（P<0.05）。结论 介入治疗用于老年动脉硬化合并糖尿病的临床综合疗效较好，术后给予氯吡格雷联合西洛他唑治疗可有效控制患者不良症状发生率，显著提高临床综合疗效。 |
| 关键词: 介入治疗 老年动脉硬化 糖尿病 |
| DOI：10.3969/j.issn.1674-3806.2016.10.15 |
| 分类号:R 587.1 |
| 基金项目: |
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| The clinical effects of clopidogrel combined with cilostazol after interventional therapy on elderly patients with arteriosclerosis and diabetes mellitus |
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GUO Tong
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Department of Cardiology, the First People′s Hospital of Xinxiang, Henan 453000, China
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| Abstract: |
| ［Abstract］ Objective To investigate the drug treatment for elderly patients with arteriosclerosis and diabetes after interventional therapy.Methods Seventy-eight elderly patients with artery sclerosis complicated with diabetes mellitus from December 2010 to December 2013 were collected as the research subjects. After the interventional therapy, the patients were divided into the control group(treated with clopidogrel treatment) and the study group(postoperative administration of clopidogrel combined with cilostazol treatment) according to the different treatment methods, with 39 cases in each group. The success rate, limb salvage rate, symptom relief rate, adverse reactions and ABI value were compared between the two groups 1 year after the treatment.Results (1)The success rate of the interventional therapy was 100%, and the rate of the limb salvage was 97.44% in the study group 1 year after the treatment. (2)The amputation rate, intermittent lameness rate and resting pain rate in the study group were significantly lower than those in the control group 1 year after the treatment(P<0.05). (3)There was no significant difference in ABI value between the two groups before the treatment. ABI values were improved in both of the two groups 1 year after the treatment, however ABI value of the research group was significantly higher than that of the control group(P<0.05).Conclusion Interventional therapy is effective for elderly patients with arteriosclerosis and diabetes. Clopidogrel in combination with cilostazol is safe and effective in the treatment of senile arteriosclerosis complicated with diabetes mellitus. |
| Key words: Interventional therapy Senile arteriosclerosis Diabetes mellitus |
