| 摘要: |
| ［摘要］ 目的 观察噻托溴铵联合N-乙酰半胱氨酸（NAC）对稳定期慢性阻塞性肺疾病(COPD)的疗效和安全性。方法 选取已经确诊的50例COPD患者，分为治疗组26例和对照组24例。治疗组用噻托溴铵联合NAC治疗,对照组用常规治疗，疗程12个月。观察治疗前后患者的肺功能、运动耐量、生活质量、急性加重次数。结果 治疗组肺功能、运动耐量、生活质量明显改善，急性加重次数减少，与对照组相比较各项指标改善更显著(P<0.05）。结论 应用噻托溴铵联合NAC可以更好地改善稳定期COPD患者的肺功能，增强运动耐量,提高生活质量，减少急性加重次数。 |
| 关键词: 慢性阻塞性肺疾病 噻托溴铵 N-乙酰半胱氨酸 |
| DOI：10.3969/j.issn.1674-3806.2016.12.21 |
| 分类号:R 563 |
| 基金项目: |
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| The curative effect of Tiotropium Bromide combined with N-acetylcysteine on chronic obstructive pulmonary disease |
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PENG Mei-hua, ZHANG Mei-xia, SUN Zhi-fen, et al
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Department of Respiratory Medicine, Cangzhou Peace Hospital, Hebei 061001, China
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| Abstract: |
| ［Abstract］ Objective To observe the efficacy and safety of tiotropium bromide combined with N-acetylcysteine(NAC) in the treatment of chronic obstructive pulmonary disease(COPD) duving the stable period.Methods Fifty COPD patients were divided into the treatment group(n=26) and the control group(n=24). The treatment group was treated with tiotropium bromide combined with NAC and the control group was given the routine treatment. The course of the treatment was 12 months for both of the two groups. The pulmonary function, exercise tolerance, quality of life, times of acute exacerbation were observed before and after the treatment.Results The lung function, exercise tolerance and quality of life in the treatment group were improved significantly better than those in the control group and the times of acute exacerbation were decreased more greatly in the treatment group.Conclusion Tiotropium bromide combined with NAC can improve the lung function and exercise tolerance in COPD patients during the stable period. |
| Key words: Chronic obstructive pulmonary disease(COPD) Tiotropium bromide N-acetylcysteine(NAC) |
