| 摘要: |
| ［摘要］ 目的 探讨刺五加注射液治疗对慢性阻塞性肺疾病（COPD）稳定期患者血浆中内皮素-1（endothelin，ET-1）、一氧化氮（nitric oxide，NO）的含量及肺功能的影响。方法 按病例编号将107例COPD稳定期患者分为治疗组和对照组，治疗组54例在西药常规治疗的基础上加用刺五加注射液治疗，对照组53例采用西药常规治疗，检测治疗前后血浆NO、ET-1水平和肺功能状况。结果 治疗前两组检测指标比较差异无统计学意义，治疗后治疗组血浆的NO、ET-1和肺功能改善较对照组明显，差异有统计学意义（P<0.05）。结论 刺五加注射液可能通过改变COPD稳定期患者血浆中NO和ET-1的含量，起到改善肺功能、延缓病情进展的效果。 |
| 关键词: 刺五加 慢性阻塞性肺疾病 一氧化氮 内皮素-1 肺功能 |
| DOI：10.3969/j.issn.1674-3806.2017.07.10 |
| 分类号:R 56 |
| 基金项目: |
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| Effect of Acanthopanax senticosus on ET-1 and NO in patients with stable COPD |
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SONG Ben-yan, HU Qiang
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Department of Respiratory Medicine, the First People′s Hospital of Liangshan, Sichuan 615000, China
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| Abstract: |
| ［Abstract］ Objective To evalute the effects of Acanthopanax senticosus injection on the levels of endothelin（ET-1） and nitric oxide（NO） and lung function in the patients with chronic obstructive pulmonary disease(COPD).Methods 107 patients with stable COPD were divided into the treatment group and the control group. The treatment group(n=54) received the conventional treatment of western medicine plus acupuncture treatment combined with Acanthopanax senticosus. The control group(n=53) received the same treatment of western medicine as the treatment group. The levels of plasma NO and ET-1 and lung function were compared between the two groups.Results The levels of plasma NO and ET-1 and lung function in the treatment group were significantly improved, and better than those in the control group(P<0.05).Conclusion Acanthopanax senticosus may effectively improve the clinical efficacy of COPD patients with stable stage of lung function and delay the progression of the disease through changing the levels of plasma NO and ET-1. |
| Key words: Acanthopanax senticosus Chronic obstructive pulmonary disease(COPD) Nitric oxide（NO） Endothelin（ET-1） Lung function |
