| 引用本文: | 蓝倩倩,陈丽妃,黄慧,沈朝兰,陈琦.共聚焦显微镜对感染性角膜炎的诊断效能[J].中国临床新医学,0,():-. |
| 蓝倩倩.共聚焦显微镜对感染性角膜炎的诊断效能[J].中国临床新医学,0,():-. |
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| 摘要: |
| 目的 评价共聚焦显微镜对细菌、真菌、单纯疱疹病毒、棘阿米巴四种感染性角膜炎的病原体的鉴别诊断能力。方法 选择该院2015年1月-2018年9月临床确诊为四种感染性角膜炎病例，采取盲法利用共聚焦显微镜进行病原体的鉴别诊断,并统计其诊断效能。结果 纳入临床确诊的感染性角膜炎共151眼，其中细菌性角膜炎43例，真菌性角膜炎56例，单疱病毒性角膜炎49例，棘阿米巴性角膜炎3例。共聚焦显微镜在细菌性角膜炎、真菌性角膜炎、单纯疱疹病毒性角膜炎、棘阿米巴性角膜炎诊断中的敏感性依次为76.74％、91.07％、77.56％、100％，特异性依次为85.19％、97.89％、92.16％、100％，Kappa值依次为0.59、0.90、0.71、1，ROC曲线下面积依次为0.810、0.945、0.849、1。结论 共聚焦显微镜对感染性角膜炎的病原学有较好的鉴别诊断能力。 |
| 关键词: 共聚焦显微镜 感染性角膜炎 诊断效能 |
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| 基金项目:广西壮族自治区卫健委自筹经费科研课题,“激光共聚焦显微镜在感染性角膜炎诊疗中的临床应用”,编号：Z2016623； |
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| Diagnostic efficiency of confocal microscopy in the infectious keratitis |
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蓝倩倩
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the People’s Hospital of Guangxi Zhuang Autonomous Region
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| Abstract: |
| 0bjective To evaluate the differential diagnosis ability of confocal microscopy for pathogens of four infectious keratitis of bacteria, fungi, herpes simplex virus and acanthamoeba. Methods We reviewed the patients diagnosed as these four infectious keratitis in clinic of our hospital. Confocal microscopy scan was performed to differential diagnosis of pathogens by blind method to analyse the diagnostic efficiency. Results 151 eyes diagnosed as infectious keratitis were included,in which there were 43 bacterial keratitis, 56 fungal keratitis, 49 herpes simplex virus keratitis and 3 acanthamoeba keratitis.The sensitivity of confocal microscopy in the diagnosis of bacterial keratitis, fungal keratitis, herpes simplex virus keratitis, and acanthamoeba keratitis were 76.74％、91.07％、77.56％、100％ respectivly. The specificity of that were 85.19％、97.89％、92.16％、100％ respectivly. The Kappa value of that were 0.59、0.90、0.71、1 respectivly. The area under the ROC curve of that were 0.810、0.945、0.849、1 respectivly. Conclusions Confocal microscopy performs well in differential diagnosis of infectious keratitis. |
| Key words: Confocal microscopy Infectious keratitis Diagnostic efficiency |
