引用本文:黄 可,杨 汀.嗜酸性粒细胞在慢性阻塞性肺疾病中的临床研究进展[J].中国临床新医学,2019,12(1):18-21.
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嗜酸性粒细胞在慢性阻塞性肺疾病中的临床研究进展
黄 可,杨 汀
100029 北京,中日友好医院呼吸与危重症医学科,国家呼吸疾病临床医学研究中心
摘要:
[摘要] 嗜酸性粒细胞在慢性阻塞性肺疾病(简称慢阻肺)患者中的作用近年来备受关注。研究发现在部分慢阻肺稳定期和急性加重期患者的循环血、气道、肺组织中均可发现嗜酸性粒细胞增高。近期的研究显示嗜酸性粒细胞与慢阻肺患者急性加重风险升高、病死率升高、肺功能下降有关,并可预测慢阻肺患者对糖皮质激素的治疗反应。该文主要综述嗜酸性粒细胞在慢阻肺患者中作为生物标志物的研究进展。
关键词:  嗜酸性粒细胞  慢性阻塞性肺疾病  糖皮质激素
DOI:10.3969/j.issn.1674-3806.2019.01.05
分类号:R 563.9
基金项目:国家自然科学基金重大研究计划培育项目(编号:91643115)
Clinical research progress of eosinophils in chronic obstructive pulmonary disease
HUANG Ke, YANG Ting
Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases, Beijing 100029, China
Abstract:
[Abstract] The role of eosinophils in patients with chronic obstructive pulmonary disease(COPD) has attracted much attention in recent years. Researchers have found that eosinophils are elevated in blood, airway and lung tissues in both stable and acute exacerbated COPD patients. Recent studies have showed that eosinophils are associated with the risk of acute exacerbation, mortality and lung function decline, and that eosinophils can predict the therapeutic response to glucocorticoids in patients with COPD. This review focuses on the research progress of eosinophils as a biomarker in COPD.
Key words:  Eosinophil  Chronic obstructive pulmonary disease(COPD)  Glucocorticoids