引用本文:闫桂芳,尹 昱,赵振彪,刘宏丽.替扎尼定治疗脑卒中后肢体痉挛的临床观察[J].中国临床新医学,2019,12(3):288-291.
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替扎尼定治疗脑卒中后肢体痉挛的临床观察
闫桂芳,尹 昱,赵振彪,刘宏丽
050050 石家庄,河北省人民医院康复医学科
摘要:
[摘要] 目的 探讨替扎尼定治疗对脑卒中后肢体痉挛患者的影响。方法 将63例脑卒中后肢体痉挛的患者,在常规康复治疗的基础上,采用随机数字表法将其分为替扎尼定治疗组(n=32)和巴氯芬对照组(n=31),在治疗前和治疗后12周采用改良Ashworth量表、临床痉挛指数、Fugl-Meyer评价表、改良Bathel指数,分别对患者的上、下肢痉挛程度、运动功能、日常生活活动能力进行评价。结果 治疗12周后,两组肢体痉挛症状明显改善,肌张力降低,患侧肢体运动功能改善,日常生活能力提高,但组间比较差异无统计学意义(P>0.05)。治疗组药物不良反应发生率低于对照组(P<0.05)。结论 替扎尼定对治疗脑卒中后肢体痉挛有较好疗效,而且临床不良反应较轻,患者耐受性好。
关键词:  替扎尼定  脑卒中  肢体痉挛
DOI:10.3969/j.issn.1674-3806.2019.03.13
分类号:R 453.9
基金项目:
Clinical observation of tizanidine in treatment of limb spasm after stroke
YAN Gui-fang, YIN Yu, ZHAO Zhen-biao, et al.
Department of Rehabilitation Medicine, Hebei General Hospital, Shijiazhuang 050050, China
Abstract:
[Abstract] Objective To investigate the effect of tizanidine on patients with limb spasm after stroke. Methods Sixty-three patients with spasm of limbs after stroke received conventional rehabilitation treatment and were randomly divided into tizanidine treatment group(n=32) and baclofen control group(n=31) by rondom number table method. The degrees of upper and lower limb spasm, motor function and activity of daily living were evaluated using the modified Ashworth score, clinic spasticity index, Fugl-Meyer assessment(FMA) and improved Bathel index respectively before and 12 weeks after treatment. Results After treatment of 12 weeks, the symptoms of limb spasm were improved significantly in both of the two groups with decreased muscle tone, improved motor function of the affected limbs and improved activity of daily living, but there were no significant differences between the two groups(P>0.05). The incidence of adverse drug reactions in the treatment group was significantly lower than that in the control group(P<0.05). Conclusion Tizanidine has a good effect on the treatment of limb spasm after stroke, and the clinical adverse reactions are slighter, and the patients have a good tolerance.
Key words:  Tizanidine  Stroke  Limb spasm