引用本文:罗朝莲,谢志满,秦英梅,刘慧芳,王 建,周欧路,蒋俊俊,叶 力,梁 浩.白介素-6在HIV合并马尔尼菲蓝状菌感染人群中的表达及作用初步研究[J].中国临床新医学,2019,12(5):514-518.
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白介素-6在HIV合并马尔尼菲蓝状菌感染人群中的表达及作用初步研究
罗朝莲,谢志满,秦英梅,刘慧芳,王 建,周欧路,蒋俊俊,叶 力,梁 浩
530021 南宁,广西艾滋病防治研究重点实验室,广西医科大学广西生物医药协同创新中心(罗朝莲,刘慧芳,王 建,周欧路,蒋俊俊,叶 力,梁 浩);530023 广西,南宁市第四人民医院感染科(谢志满,秦英梅)
摘要:
[摘要] 目的 探讨白介素-6(interleukin 6,IL-6)在人类免疫缺陷病毒(human immunodeficiency virus,HIV)合并马尔尼菲蓝状菌(talaromyces marneffei,TM)感染人群中的表达情况及作用。方法 选择在南宁市第四人民医院未接受抗病毒治疗(antiretroviral therapy,ART)的HIV感染者27例,按是否合并TM感染情况分为HIV+TM组(12例)与HIV组(15例)。比较两组的人口学资料和外周血单核细胞(peripheral blood mononuclear cell,PBMC)中IL-6的表达水平。结果 两组年龄、性别和病毒载量比较差异无统计学意义(P>0.05),HIV+TM组的CD4+ T细胞计数低于HIV组,差异有统计学意义(P=0.018)。HIV+TM组中巨噬细胞(PBMC中的一个亚群)的IL-6表达水平高于HIV组,差异有统计学意义(P=0.039)。结论 HIV+TM组PBMC中的IL-6表达较HIV组高,这可能是导致巨噬细胞免疫过度激活,促进TM感染,影响病程进展的关键因素。
关键词:  马尔尼菲蓝状菌  人类免疫缺陷病毒  外周血单核细胞  白介素-6
DOI:10.3969/j.issn.1674-3806.2019.05.11
分类号:R 512.9
基金项目:国家自然科学基金地区科学基金项目(编号:81560326);广西自然科学基金面上项目(编号:2018GXNSFAA138002);广西生物医药协同创新中心研究生创新创业项目(编号:GCICB-IE-2017012、GCICB-IE-2017013)
The expression and effect of IL-6 in HIV and Talaromyces marneffei coinfection patients
LUO Chao-lian, XIE Zhi-man, QIN Ying-mei, et al.
The Key Laboratory of AIDS Prevention and Research & Guangxi Collaborative Innovation Center for Biomedicine, Guangxi Medical University, Nanning 530021, China
Abstract:
[Abstract] Objective To explore the expression and effect of interleukin 6(IL-6) in human immunodeficiency virus(HIV) and Talaromyces marneffei(TM) coinfection patients. Methods Twenty-seven HIV-infected patients who had not received antiretroviral therapy(ART) were selected from the Fourth People′s Hospital of Nanning City, and were divided into HIV+TM group(12 cases) and HIV group(15 cases) according to the infection status of TM. The demographic data and the level of IL-6 in perpheral blood mononuclear cell(PBMC) were compared between the two groups. Results There were no significant differences in age, gender and viral load between the two groups(P>0.05), while the CD4+ T cell count of the HIV+TM group was significantly lower than that of the HIV group(P=0.018). The IL-6 expression level of macrophages(a subgroup of PBMC) in the HIV+TM group was significantly higher than that of the HIV group(P=0.039). Conclusion The IL-6 expression of HIV+TM group in PBMC is higher than HIV group, which may lead to immune hyperactivation in macrophages and may be a critical factor to promote TM infection and disease progression.
Key words:  Talaromyces marneffei(TM)  Human immunodeficiency virus(HIV)  Perpheral blood mononuclear cell(PBMC)  Interleukin 6(IL-6)