| 摘要: |
| ［摘要］ 目的 观察重组人干扰素α-2b联合保妇康栓治疗慢性宫颈糜烂合并人乳头状瘤病毒（HPV）感染的效果。方法 选取该院2013-05～2017-08收治的慢性宫颈糜烂合并HPV感染患者98例，按治疗方式的不同分为单独用药组（保妇康栓）和联合用药组（保妇康栓+重组人干扰素α-2b），比较两组患者HPV清除疗效、宫颈糜烂样改变疗效与免疫功能变化情况。结果 联合用药组的HPV清除疗效优于单独用药组，宫颈糜烂样改变疗效优于单独用药组，差异有统计学意义（P<0.05）；治疗后，联合用药组患者血清肿瘤坏死因子-α（TNF-α）水平低于单独用药组，白细胞介素-6（IL-6）水平高于单独用药组，差异有统计学意义（P<0.01）。结论 重组人干扰素α-2b联合保妇康栓治疗能提高慢性宫颈糜烂合并HPV感染患者HPV清除疗效与宫颈糜烂样改变疗效，改善患者免疫功能，适合临床推广。 |
| 关键词: 人乳头状瘤病毒感染 重组人干扰素α-2b 保妇康栓 人乳头状瘤病毒清除 免疫功能 |
| DOI：10.3969/j.issn.1674-3806.2019.10.21 |
| 分类号:R 711.32 |
| 基金项目: |
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| Effects of recombinant human interferon α-2b combined with Baofukang suppository in patients with chronic cervical erosion and HPV infection |
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JIANG Hai-fang
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Community Health Service Center of Jingxi Street, Baiyun District, Guangzhou City, Guangdong 510000, China
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| Abstract: |
| ［Abstract］ Objective To observe the effects of recombinant human interferon α-2b combined with Baofukang suppository in patients with chronic cervical erosion and human papillomavirus(HPV) infection. Methods Ninety-eight high-risk patients with chronic cervical erosion and HPV infection admitted to our hospital from May 2013 to August 2017 were divided into two groups according to different treatment methods: the single drug group(treated with Baofukang suppository) and the combination drug group(treated with Baofukang suppository+recombinant human interferon α-2b). The HPV clearance efficacy, cervical erosion-like changes and immune function changes were compared between the two groups. Results The improvements of HPV clearance and cervical erosion-like change in the combination drug group were better than those in the single drug group（P<0.05）. After treatment, the level of tumor necrosis factor-α(TNF-α) was lower and IL-6 was higher in the combination drug group than those in the single drug group(P<0.01). Conclusion Recombinant human interferon α-2b combined with Baofukang suppository can improve the efficacy of HPV scavenging and cervical erosion-like changes and immune function in the patients with chronic cervical erosion and HPV infection, which is suitable for clinicl promotion. |
| Key words: Human papillomavirus（HPV） infection Recombinant human interferon α-2b Baofukang suppository HPV clearance Immune function |
