| 摘要: |
| ［摘要］ 股骨头缺血性坏死（avascular necrosis of femoral head,ANFH）是因股骨头微循环障碍等一系列病理生理变化而最终导致股骨头坏死的疾病。微循环障碍是ANFH的最常见病因，改善股骨头微循环可促进ANFH修复与再生，血管内皮生长因子（vascular endothelial growth factor,VEGF）基因转染骨髓间充质干细胞在治疗ANFH时有显著效果，Foxc2基因转染骨髓间充质干细胞在植入坏死的股骨头后可促使间充质干细胞及成骨前体细胞向成骨细胞分化，从而修复股骨头坏死，骨桥蛋白基因高表达可促进成骨细胞的增殖分化，p53基因高表达造成骨细胞生成减少，凋亡增加，而bcl-2增高可抑制细胞凋亡。该文就ANFH的基因治疗研究进展进行综述。 |
| 关键词: 缺血性股骨头坏死 基因治疗 血管内皮生长因子 细胞凋亡 |
| DOI：10.3969/j.issn.1674-3806.2020.03.25 |
| 分类号:R 684.1 |
| 基金项目:广西自然科学基金面上项目（编号：2014GXNSFAA118186）；广西医疗卫生适宜技术开发与推广应用项目（编号：S201643）；广西自然科学基金项目（编号：0832210） |
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| Advances in gene therapy for avascular necrosis of femoral head |
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WEI Ming-zhao, LI Hong-yu
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Department of Orthopedics, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Avascular necrosis of femoral head(ANFH) is a series of physiological and pathological changes induced by blood microcirculation disturbance of femoral head, which eventually leads to diseases of femoral head necrosis. Microcirculation disturbance is the most common cause of ANFH, and improving femoral head microcirculation can promote ANFH repairment and regeneration. Vascular endothelial growth factor(VEGF) gene transfection of bone marrow mesenchymal stem cells has a significant effect in the treatment of ANFH. Forkhead box C2(Foxc2) gene transfection of bone marrow mesenchymal stem cells can promote the differentiation of mesenchymal stem cells and osteogenic precursor cells into osteoblasts after implantation of necrosis of femoral head, so as to repair the necrosis of femoral head. High expression of osteopontin(OPN) gene can promote the proliferation and differentiation of osteoblasts. High expression of p53 gene reduces the generation of osteoblasts but increases the apoptosis, and increase of bcl-2 can inhibit the apoptosis. In this paper, we review the research progress in gene therapy for ANFH. |
| Key words: Avascular necrosis of femoral head(ANFH) Gene therapy Vascular endothelial growth factor(VEGF) Apoptosis |
