引用本文:连璐雅(综述),朱海华(审校).自噬对炎症性牙槽骨吸收作用的研究进展[J].中国临床新医学,2020,13(8):833-836.
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自噬对炎症性牙槽骨吸收作用的研究进展
连璐雅(综述),朱海华(审校)
310000 杭州,浙江大学医学院附属口腔医院,浙江省口腔生物医学研究重点实验室,浙江大学口腔医学院
摘要:
[摘要] 牙周炎是牙周致病菌引发的、以牙周支持组织(尤其是骨组织)进行吸收为临床表现的慢性炎症性疾病。近年来研究发现自噬及其相关蛋白通过参与调控细胞因子和炎性小体来影响炎症进程。同时自噬及其相关蛋白作用于骨组织细胞,尤其是参与破骨细胞的形成、分化和功能发挥。该文从自噬与牙周炎症、骨组织细胞的相互作用关系以及相关研究进展作一综述,旨在阐述自噬在牙周炎导致的骨吸收进程中的作用,为牙周炎的临床治疗提供新的靶点。
关键词:  自噬  牙槽骨吸收  破骨细胞  牙周炎
DOI:10.3969/j.issn.1674-3806.2020.08.25
分类号:R 781
基金项目:国家卫健委公益性科研专项项目资助(编号:201502002)
Research progress of autophagy on inflammatory-induced alveolar bone loss
LIAN Lu-ya, ZHU Hai-hua
The Affiliated Stomatology Hospital of Zhejiang University School of Medicine, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Stomatology, Hangzhou 310000, China
Abstract:
[Abstract] Periodontitis is a chronic inflammatory disease induced by periodontal pathogens and manifested by the progressive loss of periodontal supporting tissues, especially bone tissue. Recently, researches have revealed that autophagy and its associated proteins take effects on inflammatory process by mutual regulation with cytokines and inflammasomes. Meanwhile, autophagy and its related proteins act on bone tissue cells, especially participate in the genesis, differentiation and function of osteoclasts. This review focuses on how autophagy interacts with periodontitis and bone cells and its related research progress, aiming to elaborate the role of autophagy in periodontitis-induced bone loss to provide a new target for clinical treatment of periodontitis.
Key words:  Autophagy  Alveolar bone loss  Osteoclast  Periodontitis