| 摘要: |
| ［摘要］ 目的 探讨潜在环境危险因素与儿童急性白血病发病的关系。方法 以2014-04～2020-08在广州市妇女儿童医疗中心就诊的532例初发急性白血病患儿为病例组，选取广州市妇女儿童医疗中心儿内科及儿外科门诊就诊的500例非肿瘤、非遗传性免疫/内分泌疾病患儿作为对照组，进行病例对照研究。通过问卷调查的方式记录两组儿童及其父母的基本特征、日常行为生活方式及环境暴露、父母孕期暴露情况和家庭室内外环境暴露情况等信息。采用单因素χ2检验及多因素logistic回归模型进行统计分析，并计算OR（95%CI）值。结果 按时预防接种（OR=0.085，95%CI：0.033～0.218）是儿童患急性白血病的保护因素，而儿童患传染病（OR=3.989，95%CI：2.082～7.640）、感冒次数增加（OR=2.662，95%CI：1.662～4.265）、农药/杀虫剂接触（OR=8.166，95%CI：2.304～28.938）以及母亲孕期挥发性物质接触（OR=1.874，95%CI：1.206～2.913）是儿童患急性白血病的危险因素。结论 儿童传染病史、感冒次数增加、农药/杀虫剂接触以及母亲孕期挥发性物质接触可能与儿童急性白血病发病有关。 |
| 关键词: 儿童 急性白血病 环境暴露 危险因素 |
| DOI：10.3969/j.issn.1674-3806.2021.02.03 |
| 分类号:R 733.71 |
| 基金项目:广州市科技计划项目（编号：201300000090）；国家自然科学基金资助项目（编号：81300401） |
|
| A study on the environmental risk factors of childhood acute leukemia |
|
WU Qiao-wei, GAN Wen-ting, ZHU Lu, et al.
|
|
Department of Hematology and Oncology, Guangzhou Women and Children′s Medical Center, Guangzhou Medical University, Guangdong 510623, China
|
| Abstract: |
| ［Abstract］ Objective To investigate the relationship between potential environmental risk factors and the development of childhood acute leukemia. Methods A total of 532 children with newly diagnosed acute leukemia treated in Guangzhou Women and Children′s Medical Center from April 2014 to August 2020 were selected as the case group, and 500 children with non-tumor and non-genetic immune/endocrine diseases treated in the Department of Pediatrics and the Department of Pediatric Surgery, Guangzhou Women and Children′s Medical Center were selected as the control group for a case-control study. The basic characteristics, daily behaviors and lifestyles, environmental exposures, and family indoor and outdoor environmental exposures of the children and their parents, and the parents′ exposures during pregnancy in the two groups were recorded by questionnaire survey. Univariate χ2 test and multivariate logistic regression model were used for statistical analysis, and OR(95%CI) values were calculated. Results Timely vaccination(OR=0.085, 95%CI: 0.033-0.218) was a protective factor for the children with acute leukemia, and children suffering from infectious diseases(OR=3.989,95%CI: 2.082-7.640), increased frequency of colds(OR=2.662,95%CI: 1.662-4.265), exposure to pesticides/ insecticides(OR=8.166, 95%CI: 2.304-28.938), and maternal exposure to volatile materials during pregnancy(OR=1.874, 95%CI: 1.206-2.913) were the risk factors for the children with acute leukemia. Conclusion A history of childhood infection, increased frequency of colds, exposure to pesticides/ insecticides and maternal exposure to volatile materials during pregnancy may be associated with childhood acute leukemia. |
| Key words: Children Acute leukemia Environmental exposure Risk factors |
