| 摘要: |
| ［摘要］ 目的 观察富血小板血浆联合加巴喷丁治疗带状疱疹性神经痛的临床疗效。方法 选择2019-10～2020-04于广西医科大学第二附属医院疼痛科就诊的带状疱疹性神经痛患者36例，采用随机数字表法将其分为观察组和对照组，每组18例。对照组予常规抗病毒及口服加巴喷丁治疗，观察组在此基础上加用超声引导下富血小板血浆注射靶神经治疗。比较两组临床疗效及疼痛程度，并记录两组治疗过程中出现的不良反应。结果 治疗后，两组数字评分量表（NRS）评分均呈下降趋势，与同组治疗前比较差异均有统计学意义（P<0.05）。治疗后观察组各时点的NRS评分均显著低于对照组（P<0.05）。观察组临床治愈13例，临床好转4例，无效1例；对照组临床治愈6例，临床好转6例，无效6例。观察组临床疗效优于对照组（Z=2.491，P=0.013）。两组治疗过程中均未见严重不良反应。结论 与传统单纯药物治疗比较，超声引导下富血小板血浆注射治疗带状疱疹性神经痛具有镇痛效果好、副作用少的优点，为带状疱疹性神经痛的治疗提供了新思路。 |
| 关键词: 富血小板血浆 带状疱疹 超声 |
| DOI：10.3969/j.issn.1674-3806.2021.02.07 |
| 分类号:R 751.05 |
| 基金项目:广西自然科学基金项目（编号：2017GXNSFAA198110）；广西医科大学第二附属医院国家自然科学基金培育科学基金项目（编号：GJPY2018002）；广西卫健委科研课题（编号：Z20190922）；2020年度广西高校中青年教师科研基础能力提升项目（编号：2020KY03040） |
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| Effect of platelet-rich plasma combined with gabapentin on zoster-related neuralgia |
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ZHOU Zeng-hua, LIAO Sha, HE Rui-lin, et al.
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Department of Pain Management, the Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China
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| Abstract: |
| ［Abstract］ Objective To observe the clinical efficacy of platelet-rich plasma combined with gabapentin in treatment of zoster-related neuralgia. Methods Thirty-six patients with zoster-related neuralgia treated in the Department of Pain Management of the Second Affiliated Hospital of Guangxi Medical University from October 2019 to April 2020 were selected, and were divided into observation group and control group by random number table method, with 18 cases in each group. The control group was treated with routine antiviral therapy and oral gabapentin treatment. The observation group was treated with the same treatment as the control group plus ultrasound-guided injection of platelet-rich plasma into target nerve. The clinical efficacy and pain degree were compared between the two groups, and the occurrence of adverse reactions during the treatment of the two groups were recorded. Results After treatment, the Numerical Rating Scale(NRS) scores in both groups showed a downward trend, and the differences were statistically significant compared with those before treatment in the same group(P<0.05). After treatment, the NRS scores of the observation group were significantly lower than those of the control group at each time point(P<0.05). In the observation group, 13 cases were clinically cured, 4 cases clinically improved, and 1 case ineffective; in the control group, 6 cases were clinically cured, 6 cases clinically improved, and 6 cases ineffective. The clinical effect of the observation group was better than that of the control group(Z=2.491, P=0.013). There were no serious adverse reactions during the treatment of the two groups. Conclusion Compared with traditional drug therapy alone, ultrasound-guided platelet-rich plasma injection has the advantages of better analgesic effect and less adverse reactions in treatment of zoster-related neuralgia, which provides a new idea for the treatment of zoster-related neuralgia. |
| Key words: Platelet-rich plasma Herpes zoster Ultrasound |
