| 摘要: |
| ［摘要］ 目的 探讨冠心病（CAD）患者血浆白细胞介素（IL）-38与效应性T细胞亚群的关联性。方法 选择2019年3月至2019年7月华中科技大学同济医学院附属协和医院收治的CAD患者120例，其中稳定型心绞痛（SAP）、不稳定型心绞痛（UAP）、急性心肌梗死（AMI）患者各40例，并分为SAP组、UAP组和AMI组。另选择同期胸痛综合征（CPS）患者40例作为对照组。比较四组炎症因子［IL-38、干扰素（IFN）-γ、IL-4和IL-17］、效应性T细胞亚群（Th1、Th2和Th17）水平以及其他临床资料的差异，分析IL-38与各指标的相关性。结果 四组总胆固醇、高密度脂蛋白胆固醇（HDL-C）、空腹血糖、C反应蛋白（CRP）、脑钠肽（BNP）、肌钙蛋白Ⅰ水平、左室射血分数（LVEF）及使用他汀类药物的人数比例比较差异有统计学意义（P<0.05）。AMI组IL-38、IL-17水平显著高于SAP 组（P<0.05），但与UAP组比较差异无统计学意义（P>0.05）。SAP组IL-4水平高于UAP组和AMI组，且UAP组IL-4水平高于AMI组，差异均有统计学意义（P<0.05）。AMI组IFN-γ水平高于UAP组和SAP组，且UAP组IFN-γ水平高于SAP 组，差异均有统计学意义（P<0.05）。Pearson相关分析结果显示，血浆IL-38水平与Th1、Th17、IFN-γ、IL-17、空腹血糖、CRP、肌钙蛋白Ⅰ、BNP、左心室舒张末期内径（LVEDD）呈正相关（P<0.05），与IL-4、LVEF呈负相关（P<0.05）。结论 CAD患者血浆IL-38水平显著升高，且与Th1、Th17免疫反应呈正相关。 |
| 关键词: 白细胞介素-38 冠心病 动脉粥样硬化 效应性T细胞 炎症 |
| DOI：10.3969/j.issn.1674-3806.2021.07.09 |
| 分类号:R 541.4 |
| 基金项目:国家自然科学基金项目（编号：82070310） |
|
| A study on the correlation between plasma interleukin-38 and effector T cell subsets in patients with coronary artery disease |
|
FU Yan, YU Kun-wu, PENG Yu-dong, et al.
|
|
Cardiovascular Center, Dongguan Kanghua Hospital, Guangdong 523080, China
|
| Abstract: |
| ［Abstract］ Objective To explore the correlation between plasma interleukin(IL)-38 and effector T cell subsets in patients with coronary artery disease(CAD). Methods One hundred and twenty CAD patients admitted to Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology from March 2019 to July 2019 were selected, including 40 patients with stable angina pectoris(SAP), 40 patients with unstable angina pectoris(UAP), and 40 patients with acute myocardial infarction(AMI), and the patients were divided into SAP group, UAP group and AMI group, respectively. In addition, other 40 patients with chest pain syndrome(CPS) during the same period were selected as the control group. The differences in the levels of inflammatory factors［IL-38, interferon(IFN)-γ, IL-4 and IL-17］, effector T cell subsets(Th1, Th2 and Th17) and other clinical data were compared among the four groups, and the correlation between IL-38 and each indicator was analysed. Results There were statistically significant differences in the levels of total cholesterol, high-density lipoprotein cholesterol(HDL-C), fasting blood glucose, C-reactive protein(CRP), brain natriuretic peptide(BNP) and troponin I, left ventricular ejection fraction(LVEF), and the proportion of the patients receiving statins among the four groups(P<0.05). The levels of IL-38 and IL-17 in the AMI group were significantly higher than those in the SAP group(P<0.05), but there were no significant differences in the levels of IL-38 and IL-17 between the AMI group and the UAP group(P>0.05). The level of IL-4 in the SAP group was higher than that in the UAP group and the AMI group, and the level of IL-4 in the UAP group was higher than that in the AMI group, and the differences were statistically significant(P<0.05). The level of IFN-γ in the AMI group was higher than that in the UAP group and the SAP group, and the level of IFN-γ in the UAP group was higher than that in the SAP group, and the differences were statistically significant(P<0.05). The results of Pearson correlation analysis showed that plasma IL-38 level was positively correlated with Th1, Th17, IFN-γ, IL-17, fasting blood glucose, CRP, troponin Ⅰ, BNP and left ventricular end-diastolic diameter(LVEDD)(P<0.05), and negatively correlated with IL-4 and LVEF(P<0.05). Conclusion The level of plasma IL-38 in patients with CAD is significantly increased, and is positively correlated with Th1 and Th17 immune responses. |
| Key words: Interleukin-38(IL-38) Coronary artery disease(CAD) Atherosclerosis Effector T cells Inflammation |
