| 摘要: |
| ［摘要］ 目的 分析血浆脂蛋白相关磷脂酶A2(Lp-PLA2)水平与下肢动脉硬化闭塞症（ASO）的相关性。方法 选择2018年11月至2019年1月在郑州大学第二附属医院就诊的108例拟诊为ASO的患者作为研究对象，根据踝肱指数（ABI）结果将其分为非ASO组（对照组，32例）和ASO组（研究组，76例）。收集两组患者基线资料、实验室数据，并对研究组行双下肢动脉CT血管成像（CTA）。使用二分类logistic回归分析影响患者发生ASO的因素。对研究组行Fontaine分期，根据CTA结果行泛大西洋学会联盟Ⅱ（TASCⅡ）严重程度分级，就血浆Lp-PLA2水平与研究组下肢闭塞严重程度之间进行相关性分析。结果 研究组男性、年龄、有吸烟史所占比例高于对照组，差异有统计学意义（P<0.05）。研究组同型半胱氨酸（Hcy）水平和血浆Lp-PLA2水平高于对照组，差异有统计学意义（P<0.05）。logistic回归分析显示，高年龄（OR=1.139，95%CI：1.036～1.252）和高水平的血浆Lp-PLA2（OR=1.025，95%CI：1.010～1.040）是发生ASO的危险因素。相关性分析表明，研究组血浆Lp-PLA2水平与ASO严重程度呈正相关（P<0.05）。结论 血浆Lp-PLA2是影响ASO发生的危险因素，且随着其血浆浓度的升高，下肢动脉硬化闭塞的程度加重，血浆Lp-PLA2可作为评估ASO的早期检测指标。 |
| 关键词: 下肢动脉硬化闭塞症 脂蛋白相关磷脂酶A2 同型半胱氨酸 |
| DOI：10.3969/j.issn.1674-3806.2021.07.15 |
| 分类号:R 543.5 |
| 基金项目: |
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| Analysis of correlation between the level of lipoprotein-associated phospholipase A2 and the severity of arteriosclerosis obliterans of lower extremity |
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MUNIRE Yuemaier, ZHOU Zhi-qiang, ZHOU You-xu, et al.
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Department of Vascular Surgery, the Second Affiliated Hospital of Zhengzhou University, Henan 450100, China
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| Abstract: |
| ［Abstract］ Objective To analyze the correlation between the level of lipoprotein-associated phospholipase A2(Lp-PLA2) in blood and arteriosclerosis obliterans(ASO) of lower extremity. Methods A total of 108 patients diagnosed probably with ASO in the Second Affiliated Hospital of Zhengzhou University from November 2018 to January 2019 were selected as the study subjects, and were divided into non-ASO group(the control group, 32 cases) and ASO group(the study group, 76 cases) according to the results of ankle-brachial index(ABI). The baseline data and laboratory data were collected from the two groups, and computed tomography angiography(CTA) of the arteries of the lower limbs was performed on the study group. Binary logistic regression was used to analyze the factors influencing the occurrence of ASO. Fontaine staging was performed on the study group. The severity of Trans-Atlantic Inter-Society Consensus Ⅱ(TASCⅡ) was graded according to the CTA results. The correlation between plasma Lp-PLA2 level and the severity of lower limb occlusion in the study group was analyzed. Results Male, age and the rate of having a history of smoking in the study group were significantly higher than those in the control group(P<0.05). The levels of plasma Lp-PLA2 in plasma and homocysteine(Hcy) in the study group were higher than those in the control group, and the differences were significant(P<0.05). Logistic regression analysis showed that high age(OR=1.139, 95%CI: 1.036～1.252) and high level of plasma Lp-PLA2(OR=1.025, 95%CI: 1.010～1.040) were the risk factors for ASO. Correlation analysis showed that the level of plasma Lp-PLA2 in the study group was positively correlated with the severity of ASO(P<0.05). Conclusion Plasma Lp-PLA2 in plasma is a risk factor affecting the occurrence of ASO, and the degree of arteriosclerosis occlusion of lower extremity increases with the increase of plasma concentration of plasma Lp-PLA2. Lp-PLA2 in plasma can be used as an early detection index for ASO evaluation. |
| Key words: Lower extremity arteriosclerosis obliterans Lipoprotein-associated phospholipase A2(Lp-PLA2) Homocysteine(Hcy) |
