| 摘要: |
| ［摘要］ 目的 探讨高尔基体磷蛋白3（GOLPH3）与血管内皮生长因子（VEGF）在肺腺癌中的表达及其临床意义。方法 收集安徽医科大学无锡临床学院2015年1月至2017年6月进行手术治疗的66例肺腺癌患者的临床病理资料，分析GOLPH3及VEGF表达与临床病理资料及患者预后的关系。结果 GOLPH3及VEGF在肺腺癌组织中的阳性表达率明显高于癌旁组织（P<0.05）。Cox回归分析显示TNM分期（HR=2.110，95%CI：1.048～4.250，P<0.05）、VEGF高表达（HR=2.136，95%CI：1.039～4.391，P<0.05）及GOLPH3高表达（HR=2.239，95%CI：1.075～4.661，P<0.05）是影响患者生存率的独立危险因素。结论 在肺腺癌中GOLPH3与VEGF高表达，可能促进了肿瘤的发展及转移，并且提示较差的预后。TNM分期、VEGF高表达及GOLPH3高表达是影响患者生存率的独立危险因素。 |
| 关键词: 肺腺癌 高尔基体磷蛋白3 血管内皮生长因子 预后 |
| DOI：10.3969/j.issn.1674-3806.2021.09.16 |
| 分类号:R 734.2 |
| 基金项目: |
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| Expressions of GOLPH3 and VEGF in lung adenocarcinoma and their clinical significances |
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ZANG Zhi-yi, WEI Xiao-dong
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Wuxi Clinical College of Anhui Medical University, Jiangsu 214044, China
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| Abstract: |
| ［Abstract］ Objective To explore the expressions of Golgi phosphoprotein 3(GOLPH3) and vascular endothelial growth factor(VEGF) in lung adenocarcinoma and their clinical significances. Methods The clinicopathological data of 66 patients with lung adenocarcinoma who underwent surgical treatment from January 2015 to June 2017 in Wuxi Clinical College of Anhui Medical University were collected to analyze the relationship between the expressions of GOLPH3 and VEGF and clinicopathological data and the patients′ prognosis. Results The positive expression rates of GOLPH3 and VEGF in lung adenocarcinoma tissues were significantly higher than those in paracancerous tissues(P<0.05). Cox regression analysis showed that TNM staging(HR=2.110, 95%CI: 1.048-4.250, P<0.05), high expression of VEGF(HR=2.136, 95%CI: 1.039-4.391, P<0.05) and high expression of GOLPH3(HR=2.239, 95%CI: 1.075-4.661, P<0.05) were the independent risk factors affecting the patients′ survival rate. Conclusion High expressions of GOLPH3 and VEGF in lung adenocarcinoma may promote tumor development and metastasis, and suggest a poorer prognosis. TNM staging, high expression of VEGF and high expression of GOLPH3 are the independent risk factors affecting the patients′ survival rate. |
| Key words: Lung adenocarcinoma Golgi phosphoprotein 3(GOLPH3) Vascular endothelial growth factor(VEGF) Prognosis |
