| 摘要: |
| ［摘要］ 目的 探讨血清半乳糖凝集素-3（Gal-3）与急性心肌梗死（AMI）患者新发心房颤动（AF）的关联性。方法 选择2018年10月至2019年12月广西壮族自治区人民医院收治的AMI合并新发AF患者30例（新发AF组），另选同期AMI未合并新发AF患者30例（非AF组）。通过医院病历系统收集两组的临床资料，采用多因素logistic回归分析影响AMI患者新发AF的因素，采用Pearson相关分析探讨Gal-3与B型利钠肽前体（NT-proBNP）、左房前后径的相关性。结果 新发AF组左心房前后径、NT-proBNP和血清Gal-3水平高于非AF组，差异有统计学意义（P<0.05）。多因素logistic回归分析结果显示，较高水平的血清Gal-3是促进AMI患者新发AF的危险因素（OR=2.719，P=0.006）。AMI患者的血清Gal-3水平与NT-proBNP水平、左心房前后径呈显著正相关(P<0.05)。结论 血清Gal-3水平与AMI患者新发AF密切相关，具有作为预测AMI患者新发AF标志物的潜力。 |
| 关键词: 半乳糖凝集素-3 急性心肌梗死 心房颤动 |
| DOI：10.3969/j.issn.1674-3806.2021.11.12 |
| 分类号:R 541 |
| 基金项目:广西卫生健康委科研课题项目（编号：Z20180756） |
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| A study on the association between serum galectin-3 and new-onset atrial fibrillation in patients with acute myocardial infarction |
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LI Qing-kuan, QIN Shao-ming, LU Zhi-hong, et al.
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Department of Cardiology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the association between serum galectin-3(Gal-3) and new-onset atrial fibrillation(AF) in patients with acute myocardial infarction(AMI). Methods From October 2018 to December 2019, 30 patients with AMI complicated with new-onset AF who were admitted to the People′s Hospital of Guangxi Zhuang Autonomous Region were selected as the new-onset AF group, and 30 patients with AMI but without new-onset AF during the same period were selected as the non-AF group. The clinical data of the two groups were collected through the hospital medical record system. Multivariate logistic regression analysis was used to analyze the factors influencing new-onset AF in the AMI patients, and Pearson correlation analysis was used to investigate the correlation between Gal-3 and N-terminal prohormone of brain natriuretic peptide(NT-proBNP) and the anteroposterior diameter of the left atrium. Results The anteroposterior diameter of the left atrium, the levels of NT-proBNP and serum Gal-3 in the new-onset AF group were higher than those in the non-AF group, and the differences were statistically significant between the two groups(P<0.05). The results of multivariate logistic regression analysis showed that a higher level of serum Gal-3 was a risk factor for the development of new-onset AF in the AMI patients(OR=2.719, P=0.006). The levels of serum Gal-3 in the AMI patients were significantly positively correlated with the levels of NT-proBNP and the anteroposterior diameter of the left atrium(P<0.05). Conclusion Serum Gal-3 level is closely related to new-onset AF in patients with AMI, and has the potential to be used as a marker for predicting new-onset AF in AMI patients. |
| Key words: Galectin-3(Gal-3) Acute myocardial infarction(AMI) Atrial fibrillation(AF) |
