引用本文:方年新,刘镇威,叶观生,赖政道,张 平.血清D-二聚体水平联合Caprini评分诊断肺栓塞的价值探讨[J].中国临床新医学,2022,15(4):336-340.
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血清D-二聚体水平联合Caprini评分诊断肺栓塞的价值探讨
方年新,刘镇威,叶观生,赖政道,张 平
523000 广东,南方医科大学附属东莞医院,东莞市人民医院呼吸与危重症医学科
摘要:
[摘要] 目的 探讨血清D-二聚体(D-D)水平联合Caprini评分诊断肺栓塞(PE)的价值。方法 选择2019年9月至2021年5月就诊于该院的60例PE患者作为PE组,另选同期60例非PE患者作为对照组。比较两组D-D水平、Caprini评分、凝血功能和炎性反应指标。采用ROC曲线法分析血清D-D水平、Caprini评分诊断PE的价值。采用Pearson相关分析探讨PE患者D-D水平、Caprini评分与凝血功能、炎性反应指标的相关性。结果 PE组血清D-D水平、Caprini评分、C反应蛋白(CRP)和白细胞(WBC)水平均高于对照组,纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)水平均低于对照组,两组间差异有统计学意义(P<0.05)。Pearson相关分析结果显示,PE患者D-D水平、Caprini评分与WBC、CRP呈正相关(P<0.05),与APTT、PT、FIB呈负相关(P<0.05)。ROC曲线分析结果显示,D-D水平和Caprini评分均具有诊断PE的应用价值(P<0.05),且二者联合诊断的效能更高,其灵敏度和特异度分别达到90.3%和87.5%。结论 血清D-D水平联合Caprini评分具有较好的PE诊断效能。
关键词:  肺栓塞  D-二聚体  Caprini评分  诊断效能
DOI:10.3969/j.issn.1674-3806.2022.04.11
分类号:R 563.5
基金项目:东莞市社会科技发展(重点)项目(编号:201950715001203)
Exploration on diagnostic value of serum D-dimer level combined with Caprini score in pulmonary embolism
FANG Nian-xin, LIU Zhen-wei, YE Guan-sheng, et al.
Department of Respiratory and Critical Care Medicine,Dongguan Hospital Affiliated to Southern Medical University, Dongguan People′s Hospital, Guangdong 523000, China
Abstract:
[Abstract] Objective To explore the diagnostic value of serum D-dimer(D-D) level combined with Caprini score in pulmonary embolism(PE). Methods Sixty PE patients who visited doctors in Dongguan Hospital Affiliated to Southern Medical University(Dongguan People′s Hospital) from September 2019 to May 2021 were selected as the PE group, and 60 non-PE patients during the same period were selected as the control group. The D-D level, Caprini score, coagulation function and inflammatory response indexes were compared between the two groups. The receiver operator characteristic(ROC) curve method was used to analyze the value of serum D-D level and Caprini score in the diagnosis of PE. Pearson correlation analysis was used to explore the correlation of D-D level and Caprini score with coagulation function and inflammatory response indexes in the PE patients. Results The serum D-D level, Caprini score, C-reactive protein(CRP) and white blood cell(WBC) levels in the PE group were higher than those in the control group, and the fibrinogen(FIB), activated partial thromboplastin time(APTT) and prothrombin time(PT) levels in the PE group were lower than those in the control group, and the differences were statistically significant(P<0.05). The results of Pearson correlation analysis showed that the D-D level and Caprini score in the PE patients were positively correlated with WBC and CRP(P<0.05), and negatively correlated with APTT, PT and FIB(P<0.05). The results of ROC curve analysis showed that both D-D level and Caprini score had application value in the diagnosis of PE(P<0.05), and the combined diagnostic efficiency of the two indicators was higher, with a sensitivity of 90.3% and a specificity of 87.5%. Conclusion Serum D-D level combined with Caprini score has better diagnostic efficacy for PE.
Key words:  Pulmonary embolism(PE)  D-dimer(D-D)  Caprini score  Diagnostic efficiency