引用本文:黄雪颖，李荣荣，张少杰，唐凤珠（综述），瞿申红（审校）.miR-155对变应性鼻炎患者ILC2转录因子GATA3调控作用的研究进展[J].中国临床新医学,2022,15(6):562-565.
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miR-155对变应性鼻炎患者ILC2转录因子GATA3调控作用的研究进展
黄雪颖，李荣荣，张少杰，唐凤珠（综述），瞿申红（审校）
530021　南宁，广西壮族自治区人民医院耳鼻咽喉头颈科（黄雪颖，李荣荣，张少杰，唐凤珠，瞿申红）；530021　南宁，广西医科大学研究生院（黄雪颖）
摘要:
［摘要］　Ⅱ型固有免疫细胞(ILC2)受刺激后可产生Th2型细胞因子，促进变应性鼻炎（AR）迟发相反应。miR-155在免疫系统的发育、免疫细胞的成熟分化以及维持免疫功能中都发挥至关重要的作用。GATA结合蛋白3（GATA3）是能够促进ILC2发育成熟的转录因子，而在肿瘤研究中，GATA3是miR-155的靶基因。该文对参与AR鼻黏膜中的ILC2转录因子GATA3及可干扰其表达的miR-155作一综述。
关键词:  变应性鼻炎  Ⅱ型固有免疫细胞  GATA结合蛋白3  microRNA-155
DOI：10.3969/j.issn.1674-3806.2022.06.20
分类号:R 765.21
基金项目:国家自然科学基金项目（编号：81960816）
Research progress in the regulation of miR-155 on the transcription factor GATA3 of ILC2 in allergic rhinitis patients
HUANG Xue-ying, LI Rong-rong, ZHANG Shao-jie, et al.
Department of Otorhinolaryngology Head and Neck, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China; Graduate School, Guangxi Medical University, Nanning 530021, China
Abstract:
［Abstract］　Type Ⅱ innate lymphoid cells(ILC2) are stimulated to produce T-helper lymphocyte type 2(Th2) cytokines, which promote late phase reaction in allergic rhinitis(AR). Micro ribonucleic acid-155(microRNA-155, miR-155) plays a crucial role in the development of the immune system, the maturation and differentiation of immune cells and the maintenance of immune function. GATA binding protein 3(GATA3) is a transcription factor that can promote the development and maturation of ILC2, and in tumor research, GATA3 is the target gene of miR-155. In this paper, we mainly review the transcription factor GATA3 of ILC2 which is involved in AR in nasal mucosa and miR-155 which can interfere with GATA3 expression.
Key words:  Allergic rhinitis(AR)  Type Ⅱ innate lymphoid cells(ILC2)  GATA binding protein 3(GATA3)  Micro ribonucleic acid-155(microRNA-155,miR-155)