引用本文:刘路宏,李 敏,曾思明,吴学今,陈丽妃,黄孔乾,赖小玲.577 nm波长微脉冲激光二次治疗与单次治疗重度糖尿病黄斑水肿的临床效果比较[J].中国临床新医学,2022,15(10):961-965.
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577 nm波长微脉冲激光二次治疗与单次治疗重度糖尿病黄斑水肿的临床效果比较
刘路宏,李 敏,曾思明,吴学今,陈丽妃,黄孔乾,赖小玲
530021 南宁,广西医学科学院眼科疾病医学研究所,广西壮族自治区人民医院眼科
摘要:
[摘要] 目的 比较577 nm波长微脉冲激光二次治疗与单次治疗重度糖尿病黄斑水肿(DME)的临床疗效。方法 选择2015年12月至2019年12月于广西壮族自治区人民医院确诊并接受治疗的重度DME患者60例(60眼),采用随机数字表法将其分为观察组和对照组,每组30例(30眼)。两组患者均先应用微脉冲577 nm激光治疗。观察组行二次微脉冲激光治疗(在第1次治疗6周后行第2次微脉冲光凝治疗),对照组只行1次微脉冲激光治疗。比较两组治疗前、治疗后6周及治疗后12周的最佳矫正视力(BCVA)、黄斑中心凹厚度(CMT)变化情况。结果 两组治疗后CMT均呈下降趋势,且观察组下降幅度更大(P<0.05)。在治疗后12周观察组CMT小于对照组,差异有统计学意义(P<0.05)。两组治疗后BCVA均获得改善,且观察组改善情况优于对照组(P<0.05)。在治疗后12周,观察组BCVA水平优于对照组,差异有统计学意义(P<0.05)。两组治疗后均未发生高眼压、前房炎性渗出、视野暗点、视网膜下纤维化、脉络膜新生血管(CNV)等并发症。结论 微脉冲激光二次治疗较单次微脉冲激光治疗DME的效果更优。
关键词:  糖尿病黄斑水肿  577 nm波长微脉冲激光  临床疗效
DOI:10.3969/j.issn.1674-3806.2022.10.13
分类号:R 774.5
基金项目:广西科学研究与技术开发项目(编号:桂科攻15227015)
Comparison of clinical effects between two-time treatment and single treatment with 577 nm wavelength micropulse laser on severe diabetic macular edema
LIU Lu-hong, LI Min, ZENG Si-ming, et al.
Institute of Ophthalmic Diseases, Guangxi Academy of Medical Sciences & Department of Ophthalmology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
Abstract:
[Abstract] Objective To compare the clinical effects between two-time treatment and single treatment with 577 nm wavelength micropulse laser on severe diabetic macular edema(DME). Methods Sixty severe DME patients(60 eyes) diagnosed and treated in the People′s Hospital of Guangxi Zhuang Autonomous Region from December 2015 to December 2019 were selected. They were divided into observation group and control group by random number table method, with 30 cases(30 eyes) in each group. The patients in both groups were treated with 577 nm wavelength micropulse laser first. The observation group received two-time treatment with micropulse laser(the second micropulse photocoagulation therapy was performed 6 weeks after the first treatment of micropulse laser), and the control group received only one-time treatment with micropulse laser. The changes of best corrected visual acuity(BCVA) and central macular thickness(CMT) were compared between the two groups before treatment, 6 weeks after treatment and 12 weeks after treatment. Results After treatment, CMT showed a downward trend in both groups, and the decrease in the observation group was greater(P<0.05). The CMT of the observation group was smaller than that of the control group 12 weeks after treatment, and the difference was statistically significant(P<0.05). After treatment, BCVA was improved in both groups, and the improvement in the observation group was better than that in the control group(P<0.05). The level of BCVA in the observation group was better than that in the control group 12 weeks after treatment, and the difference was statistically significant(P<0.05). There were no complications such as intraocular hypertension, anterior chamber inflammatory exudation, visual field scotoma, subretinal fibrosis, and choroidal neovascularization(CNV) in both groups after treatment. Conclusion The effect of two-time treatment with micropulse laser is better than that of single treatment with micropulse laser on DME.
Key words:  Diabetic macular edema(DME)  577 nm wavelength micropulse laser  Clinical efficacy