| 摘要: |
| ［摘要］ 目的 分析基于性别及发病年龄在中国南方帕金森病(PD)患者中的临床特征。方法 选择2017—2019年广东省第二人民医院收治的PD患者1 300例，其中男性739例，女性561例；早发型PD（EOPD）200例，晚发型PD（LOPD）1 100例，均完成各项量表测评。结果 （1）与男性PD患者相比，女性PD患者平均起病年龄更小，焦虑、抑郁、头痛等程度更严重，以震颤为首发症状的发生率更高，差异有统计学意义（P<0.05）。（2）与EOPD患者相比，LOPD患者平均起病年龄更大、病程更短，病程进展更快，发生便秘、性欲改变等比例明显增高，以僵硬为首发症状的发生率也更低，差异有统计学意义（P<0.05）。结论 在中国南方地区，不同发病年龄和性别在PD患者临床症状方面存在差异性。 |
| 关键词: 帕金森病 发病年龄 性别 临床特征 |
| DOI：10.3969/j.issn.1674-3806.2022.12.04 |
| 分类号:R 741 |
| 基金项目:广东省自然基金-自由项目（编号：2018A030313649） |
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| Analysis of clinical features of Parkinson ′s disease patients in southern China based on gender and age of onset |
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TANG Hong-yin, LIAO Xiang-lian, LI Gui-hua
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Department of Neurology, Guangdong Second Provincial General Hospital, Guangzhou 510317,China; Second Clinical Medical College, Southern Medical University, Guangzhou 510515, China
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| Abstract: |
| ［Abstract］ Objective To analyse the clinical features of Parkinson′s disease(PD) patients in southern China based on gender and age of onset. Methods A total of 1 300 PD patients［including 739 males and 561 females, and 200 early-onset PD(EOPD) patients and 1 100 late-onset PD(LOPD) patients］ were selected from Guangdong Second Provincial General Hospital during 2017 and 2019, all of whom completed the assessment of all the scales. Results (1)The female PD patients had a younger mean age of onset, more severe anxiety, more depression, and more headache, and a higher incidence of tremor as the first symptom compared with the male PD patients and the differences were significant(P<0.05). (2)The LOPD patients had an older mean age of onset, shorter disease duration, faster disease progression, significantly higher rates of constipation, significantly higher rates of libido changes, and a lower incidence of stiffness as the first symptom compared with the EOPD patients and the differences were significant(P<0.05). Conclusion In southern China, there are differences in the clinical symptoms of PD patients according to age of onset and gender. |
| Key words: Parkinson′s disease(PD) Age of onset Gender Clinical feature |
