| 摘要: |
| ［摘要］ 目的 探讨单纯性肥胖儿童综合减重干预后维生素D水平变化及作用。方法 选择2020年10月至2021年3月武汉市某小学的体检儿童作为研究对象，年龄7～14岁，其中单纯性肥胖儿童43例（肥胖组），体重（Wt）正常儿童50名（对照组）。对肥胖组进行3个月的综合减重干预，内容包括饮食、运动指导和健康宣教等。检测正常组及肥胖组干预前后血清25羟基维生素D［25-（OH）D］水平，以及人体学指标和代谢相关指标。结果 与对照组相比，干预前肥胖组Wt、腰围（WC）、体质量指数（BMI）、BMI-Z、体脂率（PBF）、空腹血胰岛素（FINS）、稳态模型胰岛素抵抗指数（HOMA-IR）、甘油三酯（TG）更高，空腹血糖（FBG）、高密度脂蛋白胆固醇（HDL-C）水平更低，差异有统计学意义（P<0.05）。经干预后，肥胖组的WC减小，BMI-Z、25-（OH）D水平降低，总胆固醇（TC）水平升高，与干预前比较差异有统计学意义（P<0.05）。Pearson相关分析结果显示25-（OH）D与Wt、WC、BMI、BMI-Z、FINS、HOMA-IR呈负相关（P<0.05），与HDL-C呈正相关（P<0.05）。多重线性回归分析结果显示，△25-（OH）D与△WC（P<0.01）、△FBG（P<0.05）呈负关联，提示25-（OH）D水平下降水平越大，WC、FBG降低越小。结论 维生素D与单纯性肥胖儿童机体代谢指标水平密切相关，维生素D水平下降会影响单纯性肥胖儿童的减重效果。 |
| 关键词: 儿童 单纯性肥胖 维生素D 减重干预 |
| DOI：10.3969/j.issn.1674-3806.2023.02.08 |
| 分类号:R 725.8 |
| 基金项目:湖北省中央引导地方科技发展专项（编号：2019ZYYD051） |
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| An exploration on the changes and effects of vitamin D levels in children with simple obesity after comprehensive weight loss intervention |
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LI Shi-han, LI Rui-zhen, HE Pei-ling, et al.
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School of Medicine of Jianghan University, Hubei 430056, China; Department of Child Healthcare, Wuhan Children′s Hospital, Hubei 430016, China
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| Abstract: |
| ［Abstract］ Objective To explore the changes and effects of vitamin D levels in children with simple obesity after comprehensive weight loss intervention. Methods The children were selected as the research subjects from a primary school in Wuhan during October 2020 and March 2021, aged from 7 to 14 years, among whom 43 cases were simple obese children(the obese group) and 50 cases were normal weight(Wt) children(the control group). In the obese group, comprehensive weight loss intervention was carried out for 3 months, including diet, exercise guidance and health education. The levels of serum 25-hydroxyvitamin D［25-(OH)D］, anthropological and metabolic indicators in the normal group and the obese group were detected before and after intervention. Results Compared with the control group, the obese group had higher Wt, waist circumference(WC), body mass index(BMI), BMI-Z, percentage body fat(PBF), fasting insulin(FINS), homeostasis model assessment of insulin resistance index(HOMA-IR) and triglyceride(TG), and lower fasting blood glucose(FBG) and high-density lipoprotein cholesterol(HDL-C) level before intervention, and the differences were statistically significant(P<0.05). Compared with those before intervention, WC decreased, and the levels of BMI-Z and 25-(OH)D decreased, and the total cholesterol(TC) level increased after intervention, and the differences were statistically significant(P<0.05). The results of Pearson correlation analysis showed that 25-(OH)D was negatively correlated with Wt, WC, BMI, BMI-Z, FINS and HOMA-IR(P<0.05), and positively correlated with HDL-C(P<0.05). The results of multiple linear regression analysis showed that △25-(OH)D was negatively correlated with △WC(P<0.01) and △FBG(P<0.05), that is, the greater the decrease of 25-(OH)D, the smaller the decrease of WC and FBG. Conclusion Vitamin D is closely related to the level of metabolic indexes in children with simple obesity. The decrease of vitamin D level affects the effect of weight loss in children with simple obesity. |
| Key words: Children Simple obesity Vitamin D Weight loss intervention |
