| 摘要: |
| ［摘要］ 目的 观察生物反馈（BF）联合普芦卡必利治疗老年功能性便秘（FC）的效果。方法 选择2020年7月至2021年12月苏州科技城医院收治的老年FC患者84例，采用随机数字表法分为观察组和对照组，每组42例。观察组采用BF疗法联合普芦卡必利进行治疗，对照组采用普芦卡必利进行治疗，连续治疗6周。比较两组的临床疗效、便秘评分、每周自发性完全排便（SCBM）次数、复发率和不良反应发生情况。结果 与治疗前比较，观察组和对照组治疗后的便秘评分降低，每周SCBM次数增加，差异有统计学意义（P<0.05），且观察组较对照组改善更显著（P<0.05）。观察组总有效率高于对照组，差异有统计学意义（83.33% vs 61.90%， χ2=4.850，P=0.028）。随访3个月，观察组复发5例（11.90%），对照组12例（28.57%），两组复发率比较差异有统计学意义（χ2=30.612，P<0.001）。两组不良反应发生率比较差异无统计学意义（7.14% vs 9.52%， χ2=0.000，P=1.000）。结论 BF联合普芦卡必利能够有效治疗老年FC，复发率低，且安全性良好。 |
| 关键词: 功能性便秘 生物反馈 普芦卡必利 疗效 |
| DOI：10.3969/j.issn.1674-3806.2023.02.15 |
| 分类号:R 574.4 |
| 基金项目: |
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| Observation on the clinical efficacy of biofeedback combined with prucalopride in treatment of senile functional constipation |
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CHENG Xiu-qin, WANG Liang-jing, PAN Shu-bo, et al.
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Department of Gastroenterology, Suzhou Science and Technology Town Hospital, Jiangsu 215153, China
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| Abstract: |
| ［Abstract］ Objective To observe the efficacy of biofeedback(BF) combined with prucalopride in treatment of senile functional constipation(FC). Methods Eighty-four elderly patients with FC who were admitted to Suzhou Science and Technology Town Hospital from July 2020 to December 2021 were selected and randomly divided into observation group and control group by random number table method, with 42 cases in each group. The observation group was treated with BF therapy combined with prucalopride, while the control group was treated with prucalopride for 6 consecutive weeks. The clinical efficacy, constipation score, frequency of weekly total spontaneous complete bowel movement(SCBM), recurrence rate and the occurrence of adverse reactions were compared between the two groups. Results Compared with those before treatment, the constipation scores in the observation group and the control group after treatment were decreased, and the frequency of weekly total SCBM was increased, and the differences were statistically significant(P<0.05), and the observation group improved more significantly than the control group(P<0.05). The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(83.33% vs 61.90%, χ2=4.850, P=0.028). During 3 months of the follow-up, 5 cases(11.90%) relapsed in the observation group and 12 cases(28.57%) in the control group. There was a statistically significant difference in the recurrence rate between the two groups(χ2=30.612, P<0.001). There was no significant difference in the incidence of adverse reactions between the two groups(7.14% vs 9.52%, χ2=0.000, P=1.000). Conclusion BF combined with prucalopride can effectively treat FC in the elderly patients, with a low recurrence rate and good safety. |
| Key words: Functional constipation(FC) Biofeedback(BF) Prucalopride Clinical efficacy |
