| 摘要: |
| ［摘要］ 目的 探讨整合素β4（ITGB4）蛋白在老年甲状腺乳头状癌组织中的表达水平及临床意义。方法 招募2019年8月至2020年8月于海口市中医医院接受全甲状腺切除术治疗的甲状腺乳头状癌老年患者80例，另选取同期接受手术治疗的结节性甲状腺肿患者50例作为对照。术中切除甲状腺乳头状癌组织及癌旁组织、结节性甲状腺肿病灶组织进行免疫组化染色，采用Western blot法检测ITGB4蛋白表达水平。分析ITGB4蛋白表达水平与老年甲状腺乳头状癌患者临床病理特征及预后情况的关联性。结果 ITGB4蛋白主要表达于细胞质中。甲状腺乳头状癌组织ITGB4蛋白表达水平显著高于癌旁组织及结节性甲状腺肿组织（P<0.05），癌旁组织及结节性甲状腺肿组织ITGB4蛋白表达水平差异无统计学意义（P>0.05）。与TNM分期为Ⅰ～Ⅱ期患者相比，Ⅲ～Ⅳ期患者ITGB4蛋白表达水平更高。与无淋巴结转移患者相比，发生淋巴结转移患者ITGB4蛋白表达水平更高。与高分化患者相比，中、低分化患者ITGB4蛋白表达水平更高，且低分化患者的表达水平较中分化患者更高，差异均有统计学意义（P<0.05）。甲状腺乳头状癌患者ITGB4低表达组的复发、生存预后情况显著优于高表达组（P<0.05）。结论 ITGB4蛋白在老年甲状腺乳头状癌中呈高表达，且与TNM分期、无淋巴结转移、分化程度显著相关，有助于预测患者预后。 |
| 关键词: 甲状腺乳头状癌 整合素β4 临床意义 预后 |
| DOI：10.3969/j.issn.1674-3806.2023.07.19 |
| 分类号:R 736.2 |
| 基金项目:海南自然科学基金面上项目（编号：20168323） |
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| Expression levels of integrin β4 protein in papillary thyroid carcinoma tissues of elderly patients and their clinical significance |
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LI Zu-jin, WU Min, SUN Chuan-yan
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Department of General Surgery, Haikou Hospital of Traditional Chinese Medicine, Hainan 570000, China
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| Abstract: |
| ［Abstract］ Objective To investigate the expression levels of integrin β4(ITGB4) protein in papillary thyroid carcinoma tissues of elderly patients and their clinical significance. Methods Eighty elderly patients with papillary thyroid carcinoma who received total thyroidectomy in Haikou Hospital of Traditional Chinese Medicine from August 2019 to August 2020 were recruited, and other 50 patients with nodular goiter who received surgical treatment during the same period were selected as controls. The papillary carcinoma tissues of the thyroid and their para-cancerous tissues, and the nodular goiter lesion tissues were resected during operation and immunohistochemical staining was performed. The ITGB4 protein expression level was detected by Western blot method. The correlations of ITGB4 protein expression level with the clinicopathological features and prognosis of elderly papillary thyroid carcinoma patients were analyzed. Results The ITGB4 protein was mainly expressed in the cytoplasm. The expression level of ITGB4 protein in the papillary thyroid carcinoma tissues was significantly higher than that in the para-cancerous tissues and the nodular goiter tissues(P<0.05), but there was no significant difference in the expression level of ITGB4 protein between the para-cancerous tissues and the nodular goiter tissues(P>0.05). Compared with those in the patients with TNM stage Ⅰ-Ⅱ, the ITGB4 protein expression levels in the patients with TNM stage Ⅲ -Ⅳ were high. Compared with that in the patients without lymph node metastasis, the ITGB4 protein expression level in the patients with lymph node metastasis was high. Compared with the highly differentiated patients, the medium-differentiated patients and the low-differentiated patients had high ITGB4 protein expression levels, and the expression level in the low-differentiated patients was higher than that in the medium-differentiated patients, and the differences were statistically significant(P<0.05). For the patients with papillary thyroid carcinoma, the recurrence, survival and prognosis of the low ITGB4 expression group were significantly better than those of the high ITGB4 expression group(P<0.05). Conclusion ITGB4 protein is highly expressed in the elderly patients with papillary thyroid carcinoma, and is significantly correlated with TNM stage, absence of lymph node metastasis, and degree of differentiation, which helps to predict the prognosis of the patients. |
| Key words: Papillary thyroid carcinoma Integrin β4(ITGB4) Clinical significance Prognosis |
