| 摘要: |
| ［摘要］ 骨肉瘤(OS)是一种好发于儿童和青少年的原发性恶性骨肿瘤，其传统治疗方法主要以多药化疗为主。由于其对化疗药物存在耐药性问题，探寻新的OS治疗靶点以及开展对OS化疗耐药性的相关研究尤为迫切。铁死亡是一种铁依赖性、非凋亡性的新型细胞程序性死亡方式，其特征为脂质活性氧的积累。目前，相关研究已证实铁死亡在OS的治疗、预后及降低耐药性等方面发挥着重要作用。该文对铁死亡在OS中的研究进展进行综述，以期为OS的防治提供理论依据。 |
| 关键词: 骨肉瘤 铁死亡 铁超载 |
| DOI：10.3969/j.issn.1674-3806.2023.07.23 |
| 分类号:R 738.1 |
| 基金项目:国家自然科学基金项目（编号：81260192） |
|
| Research progress of ferroptosis in prevention and treatment of osteosarcoma |
|
LI Ming, CHEN Long-ju
|
|
Department of Anatomy, Health Science Center, Hubei Minzu University, Enshi 445000, China
|
| Abstract: |
| ［Abstract］ Osteosarcoma(OS) is a kind of primary malignant bone tumor that is prone to occur in children and adolescents. Its main traditional treatment is multi-drug chemotherapy. Due to the problem of drug resistance to chemotherapy drugs, it is particularly urgent to explore new therapeutic targets for OS and carry out relevant researches on drug resistance to OS chemotherapy. Ferroptosis, an iron-dependent, non-apoptotic new type of programmed cell death, is characterized by the accumulation of lipid reactive oxygen species. At present, relevant studies have confirmed that ferroptosis plays important roles in the treatment, prognosis and reduction of drug resistance of OS. The research progress of ferroptosis in OS is reviewed in this paper to provide theoretical basis for the prevention and treatment of OS. |
| Key words: Osteosarcoma Ferroptosis Iron overload |
