| 摘要: |
| ［摘要］ 目的 观察愈瘿散外敷联合双氯芬酸钠缓释片治疗亚急性甲状腺炎（SAT）所致疼痛的临床疗效。方法 招募2020年12月至2021年7月河北省中医院内分泌科收治的SAT所致疼痛患者100例，采用随机数字表法将其分为观察组和对照组，每组50例。对照组予口服双氯芬酸钠缓释片治疗，观察组在对照组治疗方案的基础上予愈瘿散外敷治疗，两组均连续治疗2周。比较两组甲状腺疼痛消失时间、退热时间、甲状腺功能指标、疼痛介质指标、临床疗效以及复发情况。结果 观察组临床总有效率高于对照组，差异有统计学意义（98.00% vs 84.00%； χ2=4.396，P=0.036）。观察组甲状腺疼痛消失时间、退热时间均短于对照组，差异有统计学意义（P<0.05）。在治疗后，观察组血沉（ESR）、游离三碘甲腺原氨酸（FT3）、游离甲状腺素（FT4）、前列腺素E2（PGE2）、5-羟色胺（5-HT）、缓激肽（BK）和C反应蛋白（CRP）水平均低于对照组，促甲状腺激素（TSH）水平高于对照组，差异有统计学意义（P<0.05）。两组不良反应发生率及复发率比较差异无统计学意义（P>0.05）。结论 愈瘿散外敷联合双氯芬酸钠缓释片治疗SAT所致疼痛的疗效良好，可安全且快速地缓解患者疼痛症状，促进甲状腺功能的恢复。 |
| 关键词: 亚急性甲状腺炎 愈瘿散 双氯芬酸钠 疼痛介质 |
| DOI：10.3969/j.issn.1674-3806.2023.09.12 |
| 分类号:R 242 |
| 基金项目:河北省中医药管理局科研计划项目（编号：2021061） |
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| Observation on the clinical efficacy of external application of Yuying Powder combined with Diclofenac Sodium Sustained-release Tablets in treatment of pain caused by subacute thyroiditis |
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YU Xiang-hui, REN Xiao-ya, YANG Yu-fei, et al.
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Department of Endocrinology, Hebei Hospital of Traditional Chinese Medicine(Affiliated Hospital of Hebei College of Traditional Chinese Medicine), Shijiazhuang 050013, China
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| Abstract: |
| ［Abstract］ Objective To observe the clinical efficacy of external application of Yuying Powder combined with Diclofenac Sodium Sustained-release Tablets in treatment of pain caused by subacute thyroiditis(SAT). Methods One hundred patients with pain caused by SAT who were admitted to the Department of Endocrinology of Hebei Hospital of Traditional Chinese Medicine from December 2020 to July 2021 were recruited and divided into observation group and control group by random number table method, with 50 cases in each group. The control group was treated with oral Diclofenac Sodium Sustained-release Tablets, while the observation group was treated with external application of Yuying Powder on the basis of the treatment regimen of the control group. Both groups were treated for 2 weeks continuously. The time of thyroid pain disappearance, fever clearance time, thyroid function index, pain mediators index, clinical efficacy and recurrence were compared between the two groups. Results The total clinical effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(98.00% vs 84.00%; χ2=4.396, P=0.036). The time of thyroid pain disappearance and the fever clearance time in the observation group was shorter than that in the control group, and the difference was statistically significant(P<0.05). After treatment, the levels of erythrocyte sedimentation rate(ESR), free triiodothyronine(FT3), free thyroxine(FT4), prostaglandin E2(PGE2), 5-hydroxytryptamine(5-HT), bradykinin(BK) and C-reactive protein(CRP) in the observation group were lower than those in the control group, and the level of thyroid-stimulating hormone(TSH) in the observation group was higher than that in the control group, and the differences were statistically significant(P<0.05). There were no significant differences in the incidence of adverse reactions and the recurrence rate between the two groups(P>0.05). Conclusion The combination of external application of Yuying Powder and oral Diclofenac Sodium Sustained-release Tablets has a good therapeutic effect on SAT-induced pain. It can safely and quickly relieve the patients′ pain symptoms and promote the recovery of thyroid function. |
| Key words: Subacute thyroiditis(SAT) Yuying Powder Diclofenac sodium Pain mediators |
