| 摘要: |
| ［摘要］ 目的 探讨不同手术入路对早期甲状腺乳头状癌(PTC)患者术后循环肿瘤细胞(CTCs)水平的影响。方法 回顾性分析2017年12月至2022年3月南宁市第二人民医院收治的109例早期PTC患者的临床资料，其中接受传统开放手术者78例（A组），经腋窝入路腔镜甲状腺手术者14例（B组），经颏下前庭入路腔镜甲状腺手术者17例（C组）。比较三组围术期指标、术后住院时间，以及术后CTCs分型和水平差异。结果 A组术中出血量、清扫淋巴结数大于B组、C组，术后拔管时间、术后住院时间长于C组，差异有统计学意义（P<0.05）。B组术后拔管时间显著长于C组（P<0.05）。三组手术时间比较差异无统计学意义（P>0.05）。三组CTCs阳性率比较差异无统计学意义（P>0.05）。三组总CTCs计数及混合型CTCs计数比较差异有统计学意义（P<0.05），其中C组术后计数水平最高。结论 三种入路术式均对早期PTC取得良好的疗效，且安全性好。不同入路术式对患者术后的CTCs水平产生了一定影响，但这种差异对患者预后的影响尚需进一步验证。 |
| 关键词: 甲状腺乳头状癌 传统开放手术 经腋窝入路腔镜手术 经颏下前庭入路腔镜手术 循环肿瘤细胞 |
| DOI：10.3969/j.issn.1674-3806.2024.03.17 |
| 分类号:R 736.1 |
| 基金项目:广西医科大学青年科学基金项目（编号：GXMUYSF202130） |
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| An exploration on effects of different surgical approaches on levels of postoperative circulating tumor cells in patients with early papillary thyroid carcinoma |
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WANG Huiling, PAN Xiaoming, LYU Mian, HUANG Yonghong, XU Changqiang
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Department of Breast and Thyroid Surgery, the Second Nanning People′s Hospital(the Third Affiliated Hospital of Guangxi Medical University), Guangxi 530031, China
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| Abstract: |
| ［Abstract］ Objective To explore the effects of different surgical approaches on levels of postoperative circulating tumor cells(CTCs) in patients with early papillary thyroid carcinoma(PTC). Methods The clinical data of 109 patients with early PTC who were admitted to the Second Nanning People′s Hospital from December 2017 to March 2022 were retrospectively analyzed. Among them, 78 patients underwent traditional open surgery(group A), and 14 patients(group B) underwent endoscopic thyroidectomy via axillary approach, and 17 patients(group C) underwent endoscopic thyroidectomy via submental vestibular approach. The differences in perioperative indicators, postoperative hospital stay, and postoperative CTCs types and levels were compared among the three groups. Results The intraoperative bleeding volume and the number of lymph nodes dissected in group A were greater than those in group B and group C, and the postoperative extubation time and the duration of postoperative hospital stay in group A were longer than those in group C, and the differences were statistically significant(P<0.05). The postoperative extubation time in group B was significantly longer than that in group C(P<0.05). There was no significant difference in the operation time among the three groups(P>0.05). There was no significant difference in the positive rate of CTCs among the three groups(P>0.05). There were significant differences in total CTCs count and mixed CTCs count among the three groups(P<0.05), among which group C had the highest levels of postoperative counts. Conclusion The three surgical approaches have good efficacy and safety for early PTC. Different approaches have a certain effect on the level of postoperative CTCs, but the effects of these differences on the prognosis of the patients still need to be further verified. |
| Key words: Papillary thyroid carcinoma(PTC) Traditional open surgery Endoscopic surgery via axillary approach Endoscopic surgery via submental vestibular approach Circulating tumor cells(CTCs) |
