引用本文:张 威,蒋丰智.中性粒细胞胞外诱捕网参与血管内皮损伤在自身免疫性疾病中的研究进展[J].中国临床新医学,2024,17(6):713-716.
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中性粒细胞胞外诱捕网参与血管内皮损伤在自身免疫性疾病中的研究进展
张 威1,蒋丰智2
1.广东医科大学第一临床医学院,湛江 524023;2.广东医科大学东莞市妇幼保健院急诊科,东莞 523110
摘要:
[摘要] 血管内皮是维持血管内外环境平衡的关键屏障,其损伤会导致血浆成分外渗并积聚于周围组织,构成多种疾病的病理基础。近年来,中性粒细胞胞外诱捕网(NETs)在血管屏障损伤中的关键作用逐渐受到关注。该文对NETs参与血管内皮损伤在自身免疫性疾病中的研究进展作一综述。
关键词:  中性粒细胞胞外诱捕网  血管屏障损伤  自身免疫性疾病  血管炎
DOI:10.3969/j.issn.1674-3806.2024.06.24
分类号:R 543
基金项目:东莞市社会发展科技重点项目(编号:20211800904762)
Research progress on the involvement of neutrophil extracellular traps in vascular endothelial injury in autoimmune diseases
ZHANG Wei1, JIANG Fengzhi2
1.Guangdong Medical University the First Clinical Medical College, Zhanjiang 524023, China; 2.Department of Emergency, Dongguan Maternal and Child Health Care Hospital, Guangdong Medical University, Dongguan 523110, China
Abstract:
[Abstract] Vascular endothelium is the key barrier to maintain the balance of internal and external vascular environment. The injury of vascular endothelium can lead to the extravasation of plasma components and accumulation in the surrounding tissues, forming the pathological basis of various diseases. In recent years, the critical role of neutrophil extracellular traps(NETs) in vascular barrier injury has gradually received attention. In this paper, the research progress on the involvement of NETs in vascular endothelial injury in autoimmune diseases is reviewed.
Key words:  Neutrophil extracellular traps(NETs)  Vascular barrier injury  Autoimmune diseases  Vasculitis